V. Weissig – Mitochondrial Medicine (2 Volume set, 2015)

Автор: V. Weissig
Название книги: Mitochondrial Medicine (2 Volume set)
Формат: PDF
Жанр: Биологические науки
Страницы: 980
Качество: Изначально компьютерное, E-book

Volume I. Probing Mitochondrial Function
This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume I, Probing Mitochondrial Function focuses on methods being used for the assessment of mitochondrial function under physiological conditions as well as in healthy isolated mitochondria. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.
Содержание :
Preparation of Functional Mitochondria: A Challenging Business – Stefan Lehr, Sonja Hartwig, and Jorg Kotzka
Isolation and Quality Control of Functional Mitochondria – Sonja Hartwig, Jorg Kotzka, and Stefan Lehr
Isolation of Mitochondria-Associated ER Membranes (MAMs) and Glycosphingolipid-Enriched Microdomains (GEMs) from Brain Tissues and Neuronal Cells – Ida Annunziata, Annette Patterson, and Alessandra d’Azzo
Fluorescence Analysis of Single Mitochondria with Nanofluidic Channels – Ted Pham, Katayoun Zand, Douglas Wallace, and Peter Burke
Optical Microwell Arrays for Large-Scale Studies of Single Mitochondria Metabolic Responses – Venkata Suresh Vajrala, Emmanuel Suraniti, Bertrand Goudeau, Neso Sojic, and Stéphane Arbault
Deep Resequencing of Mitochondrial DNA – Brendan A. I. Payne, Kristian Gardner, Jonathan Coxhead, and Patrick F. Chinnery
Single-Cell Analysis of Mitochondrial DNA – Brendan A. I. Payne, Lynsey Cree, and Patrick F. Chinnery
A High-Throughput Next-Generation Sequencing Assay for the Mitochondrial Genome – Shale Dames, Karen Eilbeck, and Rong Mao
Rapid Mitochondrial DNA Isolation Method for Direct Sequencing – Wilber Quispe-Tintaya, Ryan R. White, Vasily N. Popov, Jan Vijg, and Alexander Y. Maslov
Analysis of Mitochondrial DNA and RNA Integrity by a Real-Time qPCR-Based Method – Wei Wang, Ying Esbensen, Katja Scheffler, and Lars Eide
Mitochondria-Targeted RNA Import – Geng Wang, Eriko Shimada, Mahta Nili, Carla M. Koehler, and Michael A. Teitell
Accurate Measurement of Circulating Mitochondrial DNA Content from Human Blood Samples Using Real-Time Quantitative PCR – Saima Ajaz, Anna Czajka, and Afshan Malik
mTRIP: An Imaging Tool to Investigate Mitochondrial DNA Dynamics in Physiology and Disease at the Single-Cell Resolution – Laurent Chatre and Miria Ricchetti
Simultaneous Quantification of Mitochondrial ATP and ROS Production – Liping Yu, Brian D. Fink, and William I. Sivitz
Live-Cell Assessment of Mitochondrial Reactive Oxygen Species Using Dihydroethidine – Marleen Forkink, Peter H. G. M. Willems, Werner J. H. Koopman, and Sander Grefte
Detection and Differentiation Between Peroxynitrite and Hydroperoxides Using Mitochondria-Targeted Arylboronic Acid – Jacek Zielonka, Adam Sikora, Jan Adamus, and B. Kalyanaraman
Time-Resolved Spectrometry of Mitochondrial NAD(P)H Fluorescence and Its Applications for Evaluating the Oxidative State in Living Cells – Julia Horilova, Hauke Studier, Zuzana Nadova, Pavol Miskovsky, Dusan Chorvat Jr., and Alzbeta Marcek Chorvatova
Novel Methods for Measuring the Mitochondrial Membrane Potential – Roger Springett
High-Throughput Real-Time Analysis of Cell Oxygenation Using Intracellular Oxygen-Sensitive Probes – James Hynes and Conn Carey
In Vivo Assessment of Mitochondrial Oxygen Consumption – Floor A. Harms and Egbert G. Mik
Imaging Mitochondrial Hydrogen Peroxide in Living Cells – Alexander R. Lippert, Bryan C. Dickinson, and Elizabeth J. New
Simultaneous High-Resolution Measurement of Mitochondrial Respiration and Hydrogen Peroxide Production – Gerhard Krumschnabel, Mona Fontana-Ayoub, Zuzana Sumbalova, Juliana Heidler, Kathrin Gauper, Mario Fasching, and Erich Gnaiger
Measurement of Mitochondrial NADH and FAD Autofluorescence in Live Cells – Fernando Bartolomé and Andrey Y. Abramov
Mitochondrial Coenzyme Q10 Determination via Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry – Outi Itkonen and Ursula Turpeinen
Assessing the Bioenergetic Profile of Human Pluripotent Stem Cells – Vanessa Pfiffer and Alessandro Prigione
Integrative Methods for Studying Cardiac Energetics – Philippe Diolez, Véronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Laurent Arsac, Pierre dos Santos, Pierre Jais, and Michel Haissaguerre
Computer-Based Prediction of Mitochondria-Targeting Peptides – Pier Luigi Martelli, Castrense Savojardo, Piero Fariselli, Gianluca Tasco, and Rita Casadio
Prediction of Mitochondrial Protein Function by Comparative Physiology and Phylogenetic Profiling – Yiming Cheng and Fabiana Perocchi
Assessment of Posttranslational Modification of Mitochondrial Proteins – Sudharsana R. Ande, G. Pauline Padilla-Meier, and Suresh Mishra
Assessment of Mitochondrial Protein Glutathionylation as Signaling for CO Pathway – Ana S. Almeida and Helena L. A. Vieira
High-Resolution Melting Analysis for Identifying Sequence Variations in Nuclear Genes for Assembly Factors and Structural Subunits of Cytochrome C Oxidase – Alžběta Vondráčková, Kateřina Veselá, Jiří Zeman, and Markéta Tesařová
Heterologous Inferential Analysis (HIA) as a Method to Understand the Role of Mitochondrial rRNA Mutations in Pathogenesis – Joanna L. Elson, Paul M. Smith, and Antón Vila-Sanjurjo
Analysis of Mitochondrial Dysfunction During Cell Death – Vladimir Gogvadze, Sten Orrenius, and Boris Zhivotovsky
The Use of FLIM-FRET for the Detection of Mitochondria­Associated Protein Interactions – Elizabeth J. Osterlund, Qian Liu, and David W. Andrews
Assessment of Mitochondrial Ca²⁺ Uptake – András T. Deak, Claire Jean-Quartier, Alexander I. Bondarenko, Lukas N. Groschner, Roland Malli, Wolfgang F. Graier, and Markus Waldeck-Weiermair
Qualitative Characterization of the Rat Liver Mitochondrial Lipidome Using All Ion Fragmentation on an Exactive Benchtop Orbitrap MS – Susan S. Bird, Irina G. Stavrovskaya, Rose M. Gathungu, Fateme Tousi, and Bruce S. Kristal
Characterization of Mitochondrial Populations During Stem Cell Differentiation – Petra Kerscher, Blakely S. Bussie, Katherine M. DeSimone, David A. Dunn, and Elizabeth A. Lipke
An Ex Vivo Model for Studying Mitochondrial Trafficking in Neurons – Helena Bros, Raluca Niesner, and Carmen Infante-Duarte

Volume II. Manipulating Mitochondrial Function
DQAsomes as the Prototype of Mitochondria-Targeted Pharmaceutical Nanocarriers: Preparation, Characterization, and Use – Volkmar Weissig
Predicting Mitochondrial Targeting by Small Molecule Xenobiotics Within Living Cells Using QSAR Models – Richard W. Horobin
Targeting Mitochondria with Small Molecules: The Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide – Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, and Richard C. Hartley
Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes – Parul Benein, Mohammed A. Almuteri, Ahmed S. Mehanna, and Gerard G. M. D’Souza
Synthesis and Evaluation of ¹⁸F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging – Dong-Yeon Kim and Jung-Joon Min
Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria – José Teixeira, Pedro Soares, Sofia Benfeito, Michael P. Murphy, Paulo J. Oliveira, and Fernanda Borges
Mitochondriotropic Nanoemulsified Genistein-Loaded Vehicles for Cancer Therapy – Jimmy Pham, Oliver Grundmann, and Tamer Elbayoumi
Formulation and Optimization of Mitochondria-Targeted Polymeric Nanoparticles – Sean Marrache, Rakesh K. Pathak, and Shanta Dhar
Ex Vivo Generation of Functional Immune Cells by Mitochondria-Targeted Photosensitization of Cancer Cells – Sean Marrache, Smanla Tundup, Donald A. Harn, and Shanta Dhar
Targeting the Mitochondrial Genome via a Dual Function MITO-Porter: Evaluation of mtDNA Levels and Mitochondrial Function – Yuma Yamada and Hideyoshi Harashima
Mitochondrial, Acidic, and Cytosolic pHs Determination by ³¹P NMR Spectroscopy: Design of New Sensitive Targeted pH Probes – Marcel Culcasi, Sophie Thétiot-Laurent, Ariane Atteia, and Sylvia Pietri
Methodology for Use of Mitochondria-Targeted Cations in the Field of Oxidative Stress-Related Research – Mikhail Y. Vyssokikh, Yury N. Antonenko, Konstantin G. Lyamzaev, Tatyana I. Rokitskaya, and Vladimir P. Skulachev
Synthesis and Testing of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin – Lucia Biasutto, Andrea Mattarei, and Cristina Paradisi
Evaluation of Respiration of Mitochondria in Cancer Cells Exposed to Mitochondria-Targeted Agents – Katarina Kluckova, Lan-Feng Dong, Martina Bajzikova, Jakub Rohlena, and Jiri Neuzil
The Effect of Mitochondrially Targeted Anticancer Agents on Mitochondrial (Super)Complexes – Magdalena Vondrusova, Ayanachew Bezawork-Geleta, Karishma Sachaphibulkij, Jaroslav Truksa, and Jiri Neuzil
Mitochondrial Targeting of Recombinant RNA – Ilya Dovydenko, Anne-Marie Heckel, Yann Tonin, Ali Gowher, Alya Venyaminova, Ivan Tarassov, and Nina Entelis
Mitochondrial Targeting of Catalytic RNAs – Daria Mileshina, Adnan Khan Niazi, Eliza Wyszko, Maciej Szymanski, Romain Val, Clarisse Valentin, Jan Barciszewski, and André Dietrich
Allotopic Expression of ATP6 in the Mouse as a Transgenic Model of Mitochondrial Disease – David A. Dunn and Carl A. Pinkert
Analysis of Pollutant-Induced Changes in Mitochondrial DNA Methylation – Hyang-Min Byun and Timothy M. Barrow
ETS and DEAS Studies of the Reduction of Xenobiotics in Mitochondrial Intermembrane Space – Stanislav A. Pshenichnyuk and Alberto Modelli
Analysis of Mitochondrial Morphology and Function Under Conditions of Mitofusin 2 Deficiency – Juan Pablo Muñoz and Antonio Zorzano
Yeast as a Tool to Study Mitochondrial Retrograde Pathway En Route to Cell Stress Response – Maša Ždralević, Nicoletta Guaragnella, and Sergio Giannattasio
Cell Energy Budget Platform for Assessment of Cell Metabolism – Dmitri B. Papkovsky and Alexander V. Zhdanov
Induced Pluripotent Stem Cells (iPSCs) for Modeling Mitochondrial DNA Disorders – Alessandro Prigione
Cytoplasmic Transfer Methods for Studying the Segregation of Mitochondrial DNA in Mice – Thomas Kolbe, Ralf Steinborn, and Joerg P. Burgstaller
In Vivo Visualization and Quantification of Mitochondrial Morphology in C. elegans – Reuben L. Smith, Winnok H. De Vos, Richard de Boer, Erik M. M. Manders, and Hans van der Spek
Mitochondrial DNA as a Biosensor of UV Exposure in Human Skin – Amy Bowman and Mark A. Birch-Machin
Assessment of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation – Matthias Hecker, Natascha Sommer, and Konstantin Mayer
Atomic Force Microscopy-Based Shape Analysis of Heart Mitochondria – Gi-Ja Lee and Hun-Kuk Park
Enzymatic Assays for Probing Mitochondrial Apoptosis – Zhenyu Wang, Claire Nicolas, Rodolphe Fischmeister, and Catherine Brenner
A Cybrid Cell Model for the Assessment of the Link Between Mitochondrial Deficits and Sporadic Parkinson’s Disease – Daniela M. Arduíno, A. Raquel Esteves, Russell H. Swerdlow, and Sandra M. Cardoso
Analysis of Mitochondrial Network by Imaging: Proof of Technique in Schizophrenia – Dorit Ben-Shachar, Edith Suss-Toby, and Odile Robicsek