M. Hayat – Tumors of the Central Nervous System (14 Volume set, 2015)

Автор: M. Hayat
Название книги: Tumors of the Central Nervous System (14 Volume set, 2015)
Формат: PDF
Жанр: Медицина
Страницы: 4986
Качество: Изначально компьютерное, E-book

Volume 1. Gliomas: Glioblastoma

It is recognized that scientific journals not only provide current information but also facilitate exchange of information, resulting in rapid progress. In this endeavor, the main role of scientific books is to present current information in more detail after careful additional evaluation of the investigational results, especially those of new or relatively new methods and their potential toxic side-effects.
Although subjects of diagnosis, drug development, therapy and its assessment, and prognosis of tumors of the central nervous system, cancer recurrence, and resistance to chemotherapy are scattered in a vast number of journals and books, there is need of combining these subjects in single volumes. An attempt will be made to accomplish this goal in the projected six-volume series of handbooks.
In the era of cost-effectiveness, my opinion may be a minority perspective, but it needs to be recognized that the potential for false-positive or false-negative interpretation on the basis of a single laboratory test in clinical pathology does exist. Interobservor or intraobservor variability in the interpretation of results in pathology is not uncommon. Interpretive differences often are related to the relative importance of the criteria being used.

Volume 2. Gliomas: Glioblastoma

The primary objective of this series, Tumors of the Central Nervous System, is to present the readers with the most up-to-date information on the initiation, progression, recurrence, metastasis, and treatment of the CNS tumors. As in volume 1, volume 2 has discussed in detail biomarkers and diagnosis of gliomas, especially glioblastoma. The role of a large number of biomarkers in the diagnosis of glioblastoma is included. Advantages and limitations of the use of biomarkers for diagnosis are presented. The role of TP53 gene mutation in the initiation and progression of glioblastoma is presented as well as germline mutations of this gene. Role of oncogenes and tumor suppressor genes is also discussed. Also, is discussed the role of specific genes in the resistance to drug therapy.
The importance of the use of imaging modalities (e.g., PET, CT, MRI, and SPECT) in clinical diagnosis, treatment assessment, and recurrence determination is pointed out. It is well established that early diagnosis is the key to cancer “cure”. Prognosis is highly dependent on the stage of the disease. Thus, a simple and reliable screening method would be of tremendous advantage. Imaging techniques in clinical practice are used for the staging of tumors, detection of tumor recurrence, monitoring of efficacy of therapy, and differentiation between malignant and benign tissues. In this volume, use of PET in diagnosing glioma and in assessment of biological target volume in high-grade glioma patients is explained. Also is discussed the use of MRI in glioma surgery.
Present and future therapeutic drugs for malignant gliomas are described. The efficacy of several drugs, such as cyclosporine, interferon, heparin, and cannabinoids in treating glioblastoma is explained. Effectiveness of therapies, such as resection, radiation, chemotherapy, and immunotherapy, against high-grade gliomas is detailed. Therapy for recurrent high-grade glioma with bevacizumab and irinotecan is presented. Use of dendritic cell therapy and adenoviral vectors for glioblastoma is discussed. Brainstem gliomas are also described, so is tumor-associated epilepsy.

Volume 3. Brain Tumors

In this volume, as in volumes 1 and 2, the emphasis is on the diagnosis, therapy, and prognosis of brain tumors. In addition to describing strategies for advanced brain tumor treatment, this volume presents information on understanding the unique biology of the brain and its tumors. The information contained in this volume should aid in the development of tools for better diagnosis and effective treatment of brain malignancy.
The application of various imaging techniques, including MRI, MRSI, PET, and CT, for diagnosing brain tumors including peripheral nerve sheath tumors is detailed. The use of MRS modality for classifying brain tumors is presented. This volume also contains information on the passage of malignancy to brain from tumors of other organs such as female breast and lung (tumor to tumor).

Volume 4. Brain Tumors

Volume 5. Astrocytomas, Hemangioblastomas, and Gangliogliomas

Volume 6. Spinal Tumors

Volume 7. Meningiomas and Schwannomas

Volume 8. Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma

With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted—and thus more effective.

Volume 9. Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Hemangiomas, and Craniopharyngiomas

This volume deals with various aspects of nine separate types of brain tumor. With almost 70 contributors from 17 nations, the edition offers an unrivalled thoroughness and breadth of coverage that includes the very latest research material.

Volume 10. Pineal, Pituitary, and Spinal Tumors

Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research―the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared objectivity among academics engaged in one of the most important medical endeavors of our era. It brings together the very latest work by oncologists, neurosurgeons, physicians, research scientists, and pathologists, providing the medical community with a wealth of data and results that, taken together, will advance the cause of cancer research. The volume synthesizes work on diagnosis, drug development, and therapeutic approaches that are typically scattered in a variety of journals and books. It features promising recent work in applying molecular genetics to clinical practice and evidence-based therapy, covering molecular profiling of tumors as well as a number of surgical treatments such as resection and radiosurgery. Together with its counterpart publications, it represents a much-needed central resource that will inform and guide future research efforts.

Volume 11. Pineal, Pituitary, and Spinal Tumors

Like the ten preceding volumes in the series Tumors of the Central Nervous System, this book is distinguished for its comprehensive approach, its distinguished roster of some 93 contributors representing 8 different countries and its embrace of leading-edge technology and methods. Volume 11: Imaging, Glioma and Glioblastoma, Stereotactic Radiotherapy, Spinal Cord Tumors, Meningioma, and Schwannomas concentrates on the diagnosis, prognosis and therapy of four types of tumors, namely Glioblastoma, Meningioma, Schwannoma and Spinal Tumors. The book offers an in-depth survey of a range of new technologies and their applications to tumor diagnosis, treatment and therapy assessment. The contributors explain in thorough detail a range of current and newly developed imaging methods, including molecular imaging and PET scan. Also covered is molecular profiling of brain tumors to select therapy in clinical trials of brain tumors. Discussion includes a review of such surgical treatments as resection and the application of non-invasive stereotactic radiosurgery for treating high-risk patients with brain metastasis. Additional discussion is devoted to tumor seeding.

Volume 12. Molecular Mechanisms, Children's Cancer, Treatments, and Radiosurgery

As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods.

Volume 12: Molecular Mechanisms, Children’s Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends to a large number of tumor types, including neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of brain tumors to select appropriate therapy in clinical trials of brain tumors is discussed in detail, as is the classification/diagnosis of brain tumors based on function analysis. CDK6 as the molecular regulator of neuronal differentiation in the adult brain, and the role of aquaporins in human brain tumor growth are explained. Discussion also includes tumors affecting children, including neuroblastoma and medulloblastoma. A full chapter is devoted to the role of molecular genetic alterations in medulloblastoma, and another examines survival differences between children and adults with medulloblastoma. The use of various types of imaging methods to diagnose brain tumors is explained. In-depth discussion of treatment options includes stereotactic radiosurgery, endoscopic neurosurgery, electrochemotherapy, transsphenoidal surgery, focal ablation, whole brain radiation therapy and recraniotomy.

Volume 13. Types of Tumors, Diagnosis, Ultrasonography, Surgery, Brain Metastasis, and General CNS Diseases

Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.

Volume 14. Glioma, Meningioma, Neuroblastoma, and Spinal Tumors

This fourteenth volume of the series provides comprehensive, current information on the diagnosis, therapy and prognosis of brain tumors and spinal tumors. For the readers' convenience, contributions are organized into three categories of Pineal Tumors, Pituitary Tumors, and Spinal Tumors. Readers will find discussion of various aspects of a number of tumor types, including angiocentric glioma, pilomyxoid astrocytoma, pituicytoma, pediatric low-grade gliomas, meningiomas and spinal cord tumors.

Expert oncologists, neurosurgeons, physicians, research scientists and pathologists from around the world have contributed to this extensive publication. Their chapters highlight practical experience and provide exceptional insight into the nature of cancer. The authors cover topics ranging from the use of molecular criteria in diagnosis and targeting of medicine, through evidence-based approaches, to in-depth discussion of long-term follow-up after surgery.