J. Dufour – Signaling Pathways in Liver Diseases (2016)
3.495 ₽
Автор: J. Dufour
Название книги: Signaling Pathways in Liver Diseases
Формат: PDF
Жанр: Медицина
Страницы: 520
Качество: Изначально компьютерное, E-book
Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.
With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:
Autophagy
Notch Pathway
P13K/PTEN Signaling in Liver Diseases
Sirtuins
Hepcidin and Iron
Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis
Oxidative Stress and Signaling in the Liver.
Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.
Описание
J. Dufour – Signaling Pathways in Liver Diseases (2016) — фундаментальное руководство, которое подробно разбирает молекулярные механизмы, лежащие в основе развития заболеваний печени. Книга объясняет, как сигнальные пути регулируют нормальную работу гепатоцитов и как их нарушения приводят к фиброзу, циррозу, холестазу и гепатоцеллюлярной карциноме.
Авторы анализируют ключевые сигнальные каскады — Wnt/β-catenin, Hedgehog, Notch, TGF-β, JAK/STAT, NF-κB и другие, показывая их роль в воспалении, регенерации, апоптозе и канцерогенезе печени. Особое внимание уделено взаимодействию путей и потенциальным терапевтическим мишеням для лечения хронических заболеваний печени.
- Гепатологам и гастроэнтерологам, желающим углубить понимание молекулярной патологии
- Исследователям и аспирантам, работающим в области клеточной биологии и фармакологии печени
- Врачам, занимающимся разработкой и оценкой новых таргетных препаратов
- Студентам медицинских вузов старших курсов и клиническим ординаторам
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