H. Liu – Cancer Stem Cells (2016)

Автор: H. Liu
Название книги: Cancer Stem Cells (2016)
Формат: PDF
Жанр: Медицина
Страницы: 512
Качество: Изначально компьютерное, E-book

This book introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer.
The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies.
Provides an authoritative and complete overview of cancer stem cells
Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells
Deepens a reader’s technical expertise in cancer stem cell biology
Graduate students, postdocs, and principal investigators in both academia and industry within the fields of cancer research, pharmaceutical science, molecular biology, and genetics
Preface
CSC Overview and Methodology
Introduction: Cancer Stem Cells
Introduction
Cancer Stem Cell Origins
Identification of the Cancer Stem Cell Population
Mouse Models of Cancer Stem Cell Function
Strategies for Targeting Cancer Stem Cell
Future of Cancer Stem Cell-Directed Therapies
Conclusion
List of Acronyms and Abbreviations
Overview: Cancer Stem Cell Self-Renewal
Definition of Self-renewal in Cancer Stem Cells
Assays to Measure Self-Renewal Potential of Cancer Stem Cells
Modulators of Self-Renewal in Cancer Stem Cells
Conclusion
Glossary
List of Acronyms and Abbreviations
Enrichment and Interrogation of Cancer Stem Cells
Introduction
Enrichment for Cancer Stem Cells
Functional Analysis
Conclusion and Future Directions
List of Acronyms and Abbreviations
CSCs in Representative Organ Systems
Critical Updates to the Leukemia Stem Cell Model
Introduction
The Original Leukemia Stem Cell Model
With Better Flow-Sorting Protocols, Leukemia Stem Cells Are Exclusively Progenitors, Not Hematopoietic Stem Cells, by Surface Phenotype
Evidence for Leukemia Stem Cells and Resistance
Other Mechanistic Explanations for Resistance
Master Transcription Factor Expression in Leukemia Stem Cells and Hematopoietic Stem Cells
The Most Frequent Mutations in Acute Myeloid Leukemia, in NPM1 and FLT3, Are in Committed Progenitors, Not Hematopoietic Stem Cells
Do Founder Mutations Expand Hematopoietic Stem Cells and/or Expand Committed Progen