M. Bhattacharjee – Chemistry of Antibiotics and Related Drugs (2016)

Автор: M. Bhattacharjee
Название книги: Chemistry of Antibiotics and Related Drugs (2016)
Формат: PDF
Жанр: Медицина
Страницы: 227
Качество: Изначально компьютерное, E-book

This book discusses the various classes of antibiotics and their mechanisms of action. Millions of lives have been saved by antibiotics since they were first discovered about 90 years ago. For the first few decades antibiotics had remarkable success. Encouraged by the remarkable success, in 1969 the then-US Surgeon General William Stewart testified before Congress that it was “time to close the book on infectious disease.” Today, we know how premature that statement was. More than four decades later, infectious disease still remains the leading cause of death worldwide, and ranks among the top ten causes of death in the United States. The main reason is that bacteria are becoming increasingly resistant to antibiotics. Mechanisms by which bacteria develop resistance to antibiotics are also discussed here.
This book has been written with the student in mind. The main focus is to explain how antibiotics work in curing infectious diseases and how resistance develops to the antibiotics. A background in Biochemistry is needed to understand the mechanism of action of the antibiotics. However, any background information that is needed is discussed in the book. So, it will not be necessary for the student to consult any separate biochemistry textbook in order to understand the theory of antibiotics. However, the discussion of biochemistry in this book is not meant to be complete. The only information presented is what is relevant to the understanding of antibiotics.
Contents
Introduction to Antibiotics
Development of Resistance to Antibiotics
Antibiotics That Inhibit Cell Wall Synthesis
Antimetabolites: Antibiotics That Inhibit Nucleotide Synthesis
Antibiotics That Inhibit Nucleic Acid Synthesis
Antibiotics That Inhibit Protein Synthesis
Antibiotics That Affect the Membrane and Other Structural Targets
Antifungals, Antimalarials, and Antivirals