M. Kaeberlein – Handbook of the Biology of Aging (2016)

Автор: M. Kaeberlein
Название книги: Handbook of the Biology of Aging (2016)
Формат: PDF
Жанр: Медицина
Страницы: 560
Качество: Изначально компьютерное, E-book

Handbook provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.
The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.
Basic Mechanisms of Aging: Models and Systems
Longevity as a Complex Genetic Trait
The mTOR Pathway and Aging
Sirtuins, Healthspan, and Longevity in Mammals
The Hypoxic Response and Aging
The Role of Neurosensory Systems in the Modulation of Aging
The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan
Contributions of Telomere Biology to Human Age-Related Disease
Systems Approaches to Understanding Aging
Integrative Genomics of Aging
NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging
Comparative Biology of Aging: Insights from Long-Lived Rodent Species
The Pathobiology of Human Aging
Genetics of Human Aging
The Aging Arterial Wall
Age-Related Alterations in Neural Plasticity
The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention
Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms
Cardiac Aging
Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity
On the Compression of Morbidity: From 1980 to 2015 and Beyond