Francisco Jimenez – Hair Follicle Regeneration

Автор: Francisco Jimenez
Название: Hair Follicle Regeneration
Формат: PDF
Тема: Восстановление волосяной фолликулы, Трихология
Количество страниц: 310
Качество: Компьютерное, издательское

This book aims to comprehensively review the current cell-based strategies under investigation to achieve the regeneration of human hair follicles. The unique capacity of the human hair follicle to self-renew explains why this complex “mini-organ” has always attracted so much interest as a model for researchers to study stem cell biology and regenerative medicine. The hair follicle is considered a main reservoir of cutaneous stem cells, containing several pools of epithelial, melanocyte, and mesenchymal stem cells involved in hair follicle self-regeneration and pigmentation. In addition, while some of the different follicular cell types contribute to hair shaft growth, others participate in very important interfollicular functions such as dermal remodeling, re-epithelialization after wounding, and cutaneous stem cell homeostasis.

The idea of human hair follicle regeneration either “de novo” or by activating dormant miniaturized follicles is not new, yet still continuesto arouse enormous interest in the pursuit of a definitive cure for baldness. In contrast to hair follicle regeneration in mice, the attempts made with human follicles have been disappointing in terms of efficiency. However, recent advances in stem cell biology―as well as the appearance of new technologies like 3D printing―have revived expectations in this field of research.