Walter A. Korfmacher – Mass Spectrometry for Drug Discovery and Drug Development

Автор: Walter A. Korfmacher
Название книги: Mass Spectrometry for Drug Discovery and Drug Development
Формат: PDF
Тема: Масс-спектрометрия
Страницы: 465
Качество: Изначально компьютерное, E-book

Facilitates the discovery and development of new, effective therapeutics

With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics.

Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers:

HPLC–high-resolution mass spectrometry for quantitative assays
Mass spectrometry for siRNA
Quantitative analysis of peptides
Mass spectrometry analysis of biological drugs
Applications that support medicinal chemistry investigations
Mass spectrometry imaging and profiling
Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field.