Juliet C. Gray – Immunotherapy for Pediatric Malignancies (2018)

Автор: Juliet C. Gray
Название книги: Immunotherapy for Pediatric Malignancies (2018)
Формат: PDF
Тема: Детская иммунотерапия
Страницы: 300
Качество: Изначально компьютерное, E-book

This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy.