Y. Yamaguchi – Immunotherapy of Cancer (2016)

Автор: Y. Yamaguchi
Название книги: Immunotherapy of Cancer
Формат: PDF
Жанр: Медицина
Страницы: 351
Качество: Изначально компьютерное, E-book

This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted.
With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.
Overview of Current Cancer Immunotherapy
Bacterial Preparations
Polysaccharides
BCG
αβ-T Cells
NKT Cell-Based Immunotherapy
Natural Killer Cells
γδ T Cell-Based Cancer Immunotherapy
Genetically Engineered T Cells
Peptide Vaccine
Personalized Peptide Vaccine
WT1 Peptide Vaccine for the Treatment of Malignancies: Its Development, Recent Progress, and Future Perspectives
Protein Vaccine
Dendritic Cell-Based Vaccine for Cancer
CpG Motif
Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy
Novel Adjuvants
Anti-CTLA-4 Ab
Anti-PD-1 and Anti-PD-L1 mAbs
Novel Targets of Immune Inhibitory and Stimulatory Co-signals
Regulatory T Cells
MDSC: Myeloid-Derived Suppressor Cells
Immune-Related Response Criteria and Guidance for Clinical Trials
Personalized Cancer Immunotherapy: Immune Biomarkers and Combination Immunotherapy