S. Hodgson – A Practical Guide to Human Cancer Genetics

Автор: S. Hodgson
Название книги: A Practical Guide to Human Cancer Genetics (4th edition)
Формат: PDF
Жанр: Медицина
Страницы: 434
Качество: Изначально компьютерное, E-book

This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. It is fully updated with much molecular, screening and management information. It covers risk analysis and genetic counselling for individuals with a family history of cancer. It also discusses predictive testing and the organisation of the cancer genetics service. There is information about the genes causing Mendelian cancer predisposing conditions and their mechanism of action. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines.

Since the third edition of this book, the rapid development in our understanding of
inherited cancer susceptibility has continued apace. This edition is the fi rst to be
published by Springer, and the change in publisher has been accompanied by a thorough
revision and updating on the whole book to refl ect the numerous cancer gene
discoveries since the last edition and the increasing relevance of genetic information
for prognosis and management of individuals with or at risk of inherited cancers.
Although novel discoveries facilitated by technological advances (e.g., highthroughput
second-generation sequencing) are often the most high-profi le developments
in cancer genetics, it remains true that improving the care of families affected by
inherited cancers mainly uses information about highly penetrant genes and requires a
well-coordinated multidisciplinary approach. Engaging families by sensitive counseling
practices for predictive testing and awareness of psychosocial, insurance, and ethical
issues remain fundamental to the delivery of an excellent clinical service. This edition
of this book takes into account the many new developments in our understanding of
cancer genetics – ranging from molecular pathways of oncogenesis to the translation
of scientifi c knowledge into the development of novel clinical and diagnostic services.
This edition refl ects current clinical practice in Europe and North America and should
therefore be of wide utility to those interested in clinical cancer genetics internationally.
Cancer genetics now accounts for at least half of the workload in most comprehensive
genetics centers, and a knowledge of this discipline is now germane to an
enormous range of specialties. Additionally, the increasing mainstreaming of cancer
genetics means that clinicians from many disciplines will need to gain insight
into details of cancer genetics. We therefore hope and believe that the popularity of
previous editions of this book will sustain and enhance this edition and will be helpful
to the many clinicians, laboratory scientists, and healthcare professionals who
are faced with the ever-enlarging demand for knowledge of familial cancer risks