S. Heim – Cancer Cytogenetics (2015)
2.970 ₽
Автор: S. Heim
Название книги: Cancer Cytogenetics (2015)
Формат: PDF
Жанр: Биологические науки
Страницы: 645
Качество: Изначально компьютерное, E-book
The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations.
New contributors reflecting broader international authorship and even greater expertise
Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations
Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date
Now produced in full color for enhanced clarity
Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent
Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible
Table of Contents
Preface to the Fourth Edition
How it all began: cancer cytogenetics before sequencing
Cytogenetic methods
Cytogenetic nomenclature
Nonrandom chromosome abnormalities in cancer: an overview
From chromosomes to genes: searching for pathogenetic fusions in cancer
Acute myeloid leukemia
Myelodysplastic syndromes
Chronic myeloid leukemia
Chronic myeloproliferative neoplasms
Acute lymphoblastic leukemia
Mature B ] and T ]cell neoplasms and Hodgkin lymphoma
Tumors of the upper aerodigestive tract
Tumors of the lung
Tumors of the digestive tract
Tumors of the urinary tract
Tumors of the breast
Tumors of the female genital organs
Tumors of the male genital organs
Tumors of endocrine glands
Tumors of the nervous system
Tumors of the eye
Tumors of the skin
Tumors of bone
Описание
S. Heim – Cancer Cytogenetics (2015) — фундаментальное руководство по цитогенетике рака, в котором подробно разбираются хромосомные и молекулярные изменения, лежащие в основе развития злокачественных опухолей.
Книга объясняет, как нарушения кариотипа, транслокации, делеции и амплификации генов способствуют онкогенезу, прогрессированию заболевания и формированию резистентности к терапии. Особое внимание уделено диагностической значимости цитогенетических находок в различных типах рака, включая лейкозы, лимфомы и солидные опухоли, а также современным методам анализа — от классического кариотипирования до FISH, аCGH и секвенирования следующего поколения.
- онкологам и гематологам, использующим цитогенетические данные в диагностике и лечении пациентов
- цитогенетикам и молекулярным биологам, работающим в онкологии
- врачам-лаборантам и специалистам по лабораторной диагностике
- студентам старших курсов и аспирантам медико-биологических специальностей
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