Robert Crichton — Metal-based Neurodegeneration

Автор: Robert Crichton
Название книги: Metal-based Neurodegeneration
Формат: PDF
Тема: Нейродегенеративные заболевания
Страницы: 439
Качество: Изначально компьютерное, E-book

Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.
Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides.
Topics covered include:
-Brain function, physiology and the blood-brain barrier
-Immune system and neuroinflammation
-Aging and mild cognitive impairment, MCI
-Parkinson’s Disease
-Alzheimer’s Disease
-Creutzfelt-Jakob and related prion diseases
-Alcoholic Brain Damage
-Therapeutic strategies to combat the onset and progression of neurological diseases
This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.
Contents
Brain Function, Physiology and the Blood–Brain Barrier
Role of Metal Ions in Brain Function, Metal Transport, Storage and Homoeostasis
Immune System and Neuroinflammation
Oxidative Stress in Neurodegenerative Diseases
Ageing and Mild Cognitive Impairment (MCI)
Parkinson’s Disease
Alzheimer’s Disease
Huntington’s Disease and Polyglutamine Expansion Neurodegenerative Diseases
Friedreich’s Ataxia and Diseases Associated with Expansion of Non-Coding Triplets
Creutzfeldt–Jakob and Other Prion Diseases
Amyotrophic Lateral Sclerosis
Alcoholic Brain Damage
Other Neurological Diseases
Therapeutic Strategies to Combat the Onset and Progression of Neurological Diseases
Concluding Remarks