D. Cooper – Thyroid Cancer (2016)

Автор: D. Cooper
Название книги: Thyroid Cancer
Формат: PDF
Жанр: Щитовидная железа, Эндокринология
Страницы: 412
Качество: Изначально компьютерное, E-book

There have been few instances in the fi eld of thyroidology as startling and dramatic as the epidemic of differentiated thyroid cancer in virtually all developed and developing countries around the world. Whether this is due, as many suspect, to increases in radiologic procedures and screening, or to environmental factors, such as radiation, or both continues to be a matter of intense debate. However, for the clinicians caring for the large number of new and prevalent thyroid cancer patients, there is no debate about the need for current, practical, and evidence-based information on management. This is especially the case for those with low-risk papillary thyroid cancer, who represent the vast majority of thyroid cancer patients in the twenty-fi rst century. In this group, we are learning that “less is more” in terms of the traditional treatments of surgery and radioiodine and thyroxine-suppressive therapy. On the other end of the spectrum, patients with more advanced disease are benefi tting from new targeted therapies with a host of new pharmaceutical agents, as well as local treatments directed at individual metastatic lesions. In addition, new approaches to less common forms of thyroid malignancy, including medullary thyroid cancer, anaplastic cancer, and lymphoma, are also being developed.
There are textbooks of thyroid disease in general and of thyroid cancer specifi – cally; they provide the reader with a vast amount of important information related to etiology, epidemiology, diagnosis, and management. We also know that there is a vast amount of information now available electronically that provides helpful information with the click of a mouse. The object of this text, however, is to provide the practitioner with clinically relevant information in the context of the classical medical learning tool, the case history. These illustrative thyroid cancer cases have been selected to cover the various clinical issues encountered in the care of thyroid cancer patients. The text begins with cases highlighting the diagnostic diffi culties in patients with indeterminate thyroid nodules and then provides case histories of patients with the whole range of differentiated thyroid cancer, including special circumstances, such as thyroid cancer in children and in pregnancy. Case histories of patients with advanced thyroid cancer, including those with metastatic disease receiving high-dose radioiodine and those with radioiodine-refractory disease being treated with new “targeted therapies,” are also included. All the case histories are written by an international group of authorities in the fi eld of thyroid cancer, and all recommendations are based on evidence-based clinical practice guidelines and data from the recent published literature.