J. Rowley – Chromosomal Translocations and Genome Rearrangements in Cancer (2015)

Автор: J. Rowley
Название книги: Chromosomal Translocations and Genome Rearrangements in Cancer
Формат: PDF
Жанр: Медицина
Страницы: 486
Качество: Изначально компьютерное, E-book

This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible.
The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics.
Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours.
Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.
Table of contents
A Short History of Chromosome Rearrangements and Gene Fusions in Cancer
Molecular Genetics Methods in Discovery of Chromosome Structure
Mechanisms of Recurrent Chromosomal Translocations
Chromosome Translocations, Cancer Initiation and Clonal Evolution
Common Chromosomal Fragile Sites and Cancer
Copy Number Changes in Carcinomas: Applications
Chronic Myeloid Leukaemia
Immunoglobulin and Chromosomal Translocations in B Cell Lymphomas
Chromosomal Translocations and Gene Rearrangements in Acute Lymphoblastic Leukaemia Cellular and Molecular Basis of
Acute Promyelocytic Leukaemia: From a Specific Translocation to Cure by Targeted Therapies
Chromosome Abnormalities in Acute Myeloid Leukaemia and Their Clinical Importance
Fusion Oncogenes of Sarcomas
Translocations in Ewing Sarcoma
RET and Thyroid Carcinomas
Gene Fusions in Prostate Cancer
Chromosomal Translocations in Lung Cancer
Colon and Ovarian Translocations
Pre-clinical Modelling of Chromosomal Translocations and Inversions
Protein Complex Hierarchy and Translocation Gene Products
Aberrant Transcriptional Programming in Blood Cancers