T. Cramer – Metabolism in Cancer (2016)

Автор: T. Cramer
Название книги: Metabolism in Cancer
Формат: PDF
Жанр: Медицина
Страницы: 272
Качество: Изначально компьютерное, E-book

The notion that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer. While the first description of tumor-specific changes in cellular energetics was published over 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by a rapid gain in knowledge on the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations of metabolic alterations with cancer-driving pathways were identified and are awaiting translation into diagnosis and therapy of cancer. Velocity, quantity, and complexity of these new discoveries render it difficult for researchers to keep up-to-date with the latest developments. This textbook provides concise chapters of internationally renowned experts on various important aspects of cancer-associated metabolism and hence a comprehensive platform for an overview of the central features of this exciting research field.
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells
Lactate—An Integrative Mirror of Cancer Metabolism
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer
MYC, Metabolic Synthetic Lethality, and Cancer
The Role of pH Regulation in Cancer Progression
Metabolic Features of Cancer Treatment Resistance
Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome
Imaging of Tumor Metabolism Using Positron Emission Tomography (PET)
Quantitative Analysis of Cancer Metabolism: From pSIRM to MFA
Mathematical Modeling of Cellular Metabolism
Ketogenic Diet and Cancer—a Perspective
Fasting and Caloric Restriction in Cancer Prevention and Treatment