W. Coleman – The Molecular Basis of Human Cancer (2017)

Автор: W. Coleman
Название книги: The Molecular Basis of Human Cancer
Формат: PDF
Жанр: Медицина
Страницы: 868
Качество: Изначально компьютерное, E-book

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.
The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
Table of contents
Cancer Epidemiology: Incidence and Etiology of Human Neoplasms
Essential Concepts and Techniques in Molecular Biology
Cancer Genomics
Cancer Cytogenetics
Epigenetic Basis of Human Cancer
Cancer Proteomics
An Overview of Cancer Genes
Oncogenes and the Initiation and Maintenance of Tumorigenesis
Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors
Senescence, Apoptosis, and Cancer
Novel Cancer Therapies Targeting Angiogenesis
Beyond the Primary Tumor: Progression, Invasion, and Metastasis
Simple Sequence Mutations
Single Nucleotide Polymorphisms and Cancer Susceptibility
Chromosomes and Chromosomal Instability in Human Cancer
Epigenetic Mechanisms in Cancer Development
MicroRNAs and Cancer
Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas
Viral Mechanisms in Human Carcinogenesis
Hormonal Carcinogenesis: The Role of Estrogens
Sporadic Cancers
Hereditary Cancer
Retinoblastoma: Clinical and Molecular Perspectives
Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light
Hereditary Colorectal Cancer
Hereditary Breast and Ovarian Cancer
The Molecular Basis of Prostate Carcinogenesis
Molecular Basis of Lung Carcinogenesis
Molecular Basis of Skin Carcinogenesis
Molecular Biology of Leukemias
Molecular Mechanisms in Non-Hodgkin Lymphoma
The Molecular Pathology of Head and Neck Squamous Cell Carcinoma
Ovarian Cancer
Molecular Pathology of Bone and Soft Tissue Tumors
Molecular Biology of Human Brain Tumors
Cancer Drug Discovery and Anticancer Drug Development
Biological Principles and Clinical Application of EGFR Inhibitors in Cancer
Targeting Oncoproteins for Molecular Cancer Therapy
Therapeutic Agents That Inhibit Angiogenesis
Small Molecule Inhibitors
Molecular Detection and Diagnosis of Cancer
Gene Therapy in the Treatment of Human Cancer
Personalized Medicine for the Treatment of Human Cancer