Y. Hannun – Bioactive Sphingolipids in Cancer Biology and Therapy (2015)

Автор: Y. Hannun
Название книги: Bioactive Sphingolipids in Cancer Biology and Therapy
Формат: PDF
Жанр: Медицина
Страницы: 489
Качество: Изначально компьютерное, E-book

This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.
Table of contents
Basics of Sphingolipid Metabolism and Signalling
Role of Sphingolipids in Hematological Malignancies: Lymphoproliferative Disorders
Role of Sphingolipids in Hematological Malignancies: Myeloproliferative Disorders
Sphingolipids as Mediators of Breast Cancer Progression, Metastasis, Response and Resistance to Chemotherapy
Role of Sphingolipids in Non-melanoma Skin Cancer
Dysregulation of Sphingolipid Metabolism in Melanoma: Roles in Pigmentation, Cell Survival and Tumor Progression
Colon Cancer: The Role of Sphingolipid Metabolic Enzymes
Dietary Sphingolipids in Colon Cancer Prevention
Role of Sphingolipids in Liver Cancer
Pancreatic Cancer and Sphingolipids
Sphingolipids in the Pathogenesis of Head and Neck and Lung Cancers: Translational Aspects for Therapy and Biomarker Development
The Role and Function of Sphingolipids in Glioblastoma Multiforme
Systems Biology Approaches for Studying Sphingolipid Signaling
Qualitative and Quantitative Measurements of Sphingolipids by Mass Spectrometry
Detection and Distribution of Sphingolipids in Tissue by FTICR MALDI-Imaging Mass Spectrometry
Sphingoproteomics: Proteomic Strategies to Examine Sphingolipid Biology
Utilization of Caged Ceramide and Ceramide 1-Phosphate Analogs for Monitoring Cellular Events after Photoactivation
Chemotherapy and Sphingolipid Metabolism
Chemical Probes of Sphingolipid Metabolizing Enzymes