V. Patel – Biomarkers in Kidney Disease (2016)

Автор: V. Patel
Название книги: Biomarkers in Kidney Disease (2016)
Формат: PDF
Жанр: Медицина
Страницы: 1212
Качество: Изначально компьютерное, E-book

In some countries such as the United States, kidney disease kills more people than cancers of the prostate or breast. In the United States for example there are over 15 million individuals with kidney disease. Translated to a worldwide basis, kidney disease of various aetiologies represent a significant burden on healthcare systems, affecting mortality, morbidity and also the family unit. It is therefore imperative that appropriate use is made of conventional, new and emerging biomarker platforms to aid diagnosis, treatment and an understanding of outcome measures. Biomarkers in Kidney Disease embraces a holistic approach by combining information on different conditions that affect the kidney and the use of biomarkers. Biomarkers are described in terms of conventional, new and emerging analytes, techniques, platforms and applications. It covers the latest knowledge and trends. New platforms are described which combine advances in biomedical sciences, physics, computing and chemistry.

In the present volume, Biomarkers in Kidney Disease, we have sections on
• General Aspects
• Circulating and Body Fluid Biomarkers
• Specific Diseases and Conditions
• Molecular, Cellular, and Histological Variables
• Functional and Structural Variables
• Resources
While the Editors recognize the difficulties in assigning particular chapters
to particular sections, the book has enormously wide coverage and includes the
following areas, analytes, and conditions: osmolal gap, metabolic acidosis,
metabolomics, hypoxia, micro-RNAs, creatinine, spot urine markers, neutrophil
gelatinase-associated lipocalin (NGAL), chemokines, angiotensinogen, flow
cytometry, leucocytes, lymphocytes, exosomes, N-acetyl-beta-D-glucosaminidase
(NAG), endothelin, methylated arginines, albuminuria, cystatin C,
homocysteinemia, fetal beta2-microglobulin, proteinuric biomarkers, apelin,
copeptin, BLyS and APRIL cytokines, glutathione transferase, growth arrest-specific
protein 6 (Gas6), urokinase receptor, urea nitrogen, allograft damage index (CADI),
antibody arrays, malondialdehyde, matrix metalloproteinase-2 (MMP-2), plasminogen
activator inhibitor-1 (PAI-1), fibrosis, kidney biopsies, next generation sequencing
(NGS), cell-cycle arrest biomarkers, integrin-linked kinase (ILK), molecular
biomarkers, M-type phospholipase A2 receptor, ultrasound elastography, aortic
pulse wave velocity, renal arterial resistance index, pulmonary pressure, glomerular
filtration rates, and erythrocyte width. A wide spectrum of acute and chronic
conditions are described including, nephritis, neoplastic disease, transplantation,
allograft damage, cystic fibrosis, diabetes, IgA nephropathy, focal segmental
glomerulosclerosis, renal microthrombosis, and dialysis.
There are also many other analytes and conditions described within this volume.
Finally, the last chapter is devoted to locating resource material for biomarker
discovery and applications.

The chapters are written by national or international experts and specialist. This
book is specifically designed for clinical biochemists, nephrologists, specialists
working within the field of kidney disease and treatments, health scientists, epidemiologists,
and doctors and nurses, from students to practioners at the higher level.
It is also designed to be suitable for lecturers and teachers in health care and libraries
as a reference guide.

Topics

Cancer Research
Oncology
Pharmacology / Toxicology
Series Titles (Biomarkers in Disease: Methods, Discoveries and Applications):
General Methods in Biomarker Research and Their Applications
Biomarkers in Cancer
Biomarkers in Cardiovascular Disease
Biomarkers in Kidney Disease
Biomarkers in Bone Disease
Biomarkers in Liver Disease