J. Zheng – Handbook of Ion Channels (2015)

Автор: J. Zheng
Название книги: Handbook of Ion Channels
Формат: PDF
Жанр: Биологические науки
Страницы: 673
Качество: Изначально компьютерное, E-book

Throughout their long scientific history, the concepts of cellular electricity and ion-permeable pores have been principally the province of scientists with a physical orientation who often called themselves biophysicists.* Only in the last three decades have ion channels become accessible to a much broader range of scientists. In addition to biophysicists, ion channels are now studied by
physiologists, biologists, biochemists, anatomists, molecular biologists, structural biologists, and physicians.
This handbook provides a comprehensive reference source on ion channels for students, instructors, and researchers in the field. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure, and are therefore fundamentally important for human health and disease. In nonexcitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis, and because they are often located at the surface of cells, they have the unique ability
to interact with their environment. Consequently, ion channels are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion channel measurement techniques to modeling ion channel diseases in animals, and performing human clinical trials for ion channel drugs. This book gives the reader an introduction to the technical aspects of ion channel research as well as offers an inclusive and modern guide to the properties of major ion channels.
Contents
Basic Concepts
Ion Channel Methods
Ion Channel Families
Ion Channel Regulation
Ion Channel Physiology and Diseases