E. Nieschlag – Testosterone. Action, Deficiency, Substitution (2012)

Автор: E. Nieschlag
Название книги: Testosterone. Action, Deficiency, Substitution
Формат: PDF
Жанр: Андрология, Тестостерон
Страницы: 591
Качество: Изначально компьютерное, E-book

Now in its fourth edition Testosterone: Action, Deficiency, Substitution provides the most up-to-date and comprehensive source of information on testosterone and its role in human physiology and pathology. It covers biosynthesis and mechanisms of action and reviews their effects on brain and behavior, spermatogenesis, hair growth, bones, muscles, erythropoiesis, the cardiovascular system and the prostate. The therapeutic uses of testosterone preparations are carefully evaluated as well as its abuse and detection in competitive sport. This new edition also devotes sections to exploring the effects of testosterone on female physiology and sexual function, and the experimental use of testosterone in male hormonal contraception. Testosterone: Action, Deficiency, Substitution has been written and edited by world experts in the fields of clinical andrology and endocrinology and provides a unique and invaluable guide for andrologists, endocrinologists, urologists, internists and those working in reproductive medicine.

Preface
Testosterone is the focal point of male reproductive health. Testosterone is responsible for all male characteristics, and testosterone deficiency results in hypogonadism which has an impact on the entire male organism. Testosterone plays an important role in male aging. Many diseases, especially mood disorders, cardiovascular diseases and the metabolic syndrome can be caused by testosterone deficiency, but can also result in hypogonadism. Consequently, testosterone is a key factor in the treatment of male disorders; benefits and risks of such treatment need to be balanced. The potent effects of testosterone also give rise to their misuse, prompting the establishment of sensitive detection systems, but also bearing adverse side-effects. Measuring testosterone in body fluids based on immunoassays was the basis for research in male pathophysiology over decades; however, methodology is currently shifting to gas or liquid chromatography tandem mass spectrometry. The hopes for a male hormonal contraceptive rest on testosterone as its major constituent. As estrogens derived from testosterone play a role in male physiology, testosterone also is of importance for general and sexual health in women. Finally, new therapeutic applications are expected from selective androgen receptor modulators (SARMs).
A tremendous amount of new knowledge has accumulated over the eight years since the third edition of this book on testosterone appeared. The 25 chapters of the current volume, written by worldwide leading experts in their field, encapsulate this progress. The book appeals to the clinician as well as to the basic scientist wishing for an authoritative overview of this central area of male reproductive health.
In order to synchronize the writing of the various chapters, the authors assembled at Castle Hohenkammer in Bavaria in October 2011 for three days, and finalized their writings during that time. This served to unify the work as a whole, and ensures that it represents the most up-to-date reference source on testosterone and its many facets. This coordinated effort of all contributors guarantees a long half-life of this book as an up-to-date reference source.
The editors wish to thank the authors of the various chapters for their excellent compliance and timely submission of manuscripts. We could not have concluded this task without the tireless reading capacity and help from Susan Nieschlag, who as a professional edited all manuscripts; nor would the volume have come to fruition without the skilful assistance of our secretaries Maria Schalkowski and Ina Nelles, who processed the manuscripts expediently. Finally, the project and the meeting would not have been possible without the generous support from Bayer Health Care (formerly Bayer Schering Pharma), the International Society of Andrology (ISA), the European Academy of Andrology (EAA), the German Association for Reproductive Health, the Clinical Research Group for Reproductive Medicine, Galen Pharma, Merck Serono, Ferring Pharmaceuticals and our home institutions, the Centers for Reproductive Medicine and Andrology at the Universities of Münster and Halle.
Contents
1 The medical and cultural history of testosterone and the testes
2 Testosterone: biosynthesis, transport, metabolism and (non-genomic) actions
3 Pathophysiology of the androgen receptor
4 Methodology for measuring testosterone, dihydrotestosterone and sex hormone-binding globulin in a clinical setting
5 The behavioral correlates of testosterone
6 The role of testosterone in spermatogenesis
7 Androgens and hair: a biological paradox with clinical consequences
8 Testosterone and bone
9 Androgen effects on the skeletal muscle
10 Testosterone and cardiovascular disease
11 Testosterone, obesity, diabetes and the metabolic syndrome
12 Testosterone and erection
13 Testosterone and the prostate
14 Clinical use of testosterone in hypogonadism and other conditions
15 Testosterone preparations for clinical use in males
16 Androgens in male senescence
17 Androgen therapy in non-gonadal disease
18 Review of guidelines on diagnosis and treatment of testosterone deficiency
19 Pathophysiology of estrogen action in men
20 Dehydroepiandrosterone and androstenedione
21 The state-of-the-art in the development of selective androgen receptor modulators
22 The essential role of testosterone in hormonal male contraception
23 Testosterone use in women
24 Detection of illegal use of androgens and selective androgen receptor modulators
25 Sequelae of doping with anabolic steroids
Index