D. Hatfield – Selenium. Its Molecular Biology and Role in Human Health (2016)

Автор: D. Hatfield
Название книги: Selenium. Its Molecular Biology and Role in Human Health (2016)
Формат: PDF
Жанр: Селен
Страницы: 650
Качество: Изначально компьютерное, E-book

Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function.
The purpose of the book is the same as the first three volumes which is to bring an up to date status of current research in the rapidly developing selenium field centered around the health benefits attributed to this element and how this element makes its way into protein.
In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.
Table of contents
Selenocysteine tRNA
Eukaryotic Mechanisms of Selenocysteine Incorporation and Its Reconstitution In Vitro
Probing Selenoprotein Translation by Ribosome Profiling
Pathways in De Novo Biosynthesis of Selenocysteine and Cysteine in Eukaryotes
Prokaryotic Selenoprotein Biosynthesis and Function
The Role of Selenium in Human Evolution
The Chemistry of Selenocysteine in Proteins
Evolution of Selenophosphate Synthetase
Structure and Mechanism of Selenocysteine Synthases
Mechanism, Structure, and Biological Role of Selenocysteine Lyase
Eukaryotic Selenoproteomes
Prokaryotic Selenoproteins and Selenoproteomes
Functional Genomics of Selenoproteins and Se-responsive Pathways
Selenium Regulation of the Selenoprotein and Non-selenoprotein Transcriptomes in a Variety of Species
Thioredoxin Reductase 1 as an Anticancer Drug Target
Basics and News on Glutathione Peroxidases
Glutathione Peroxidase 4
The 15 kDa Selenoprotein: Insights into Its Regulation and Function
Selenoprotein K and Protein Palmitoylation in Regulating Immune Cell Functions
Selenoprotein M: Structure, Expression and Functional Relevance
Selenoprotein P and Selenium Distribution in Mammals
Selenoprotein T: From Discovery to Functional Studies Using Conditional Knockout Mice
Biochemistry and Function of Methionine Sulfoxide Reductase
Selenium: Dietary Sources, Human Nutritional Requirements and Intake Across Populations