George Plopper — Lewins Cells (Third edition)

Автор: George Plopper
Название книги: Lewins Cells (Third edition)
Формат: PDF
Жанр: Биология
Страницы: 1080
Качество: Изначально компьютерное, E-book

The ideal text for undergraduate and graduate students in advanced cell biology courses Extraordinary technological advances in the last century have fundamentally altered the way we ask questions about biology, and undergraduate and graduate students must have the necessary tools to investigate the world of the cell. The ideal text for students in advanced cell biology courses, Lewin’s CELLS, Third Edition continues to offer a comprehensive, rigorous overview of the structure, organization, growth, regulation, movements, and interactions of cells, with an emphasis on eukaryotic cells. The text provides students with a solid grounding in the concepts and mechanisms underlying cell structure and function, and will leave them with a firm foundation in cell biology as well as a “big picture” view of the world of the cell. Revised and updated to reflect the most recent research in cell biology, Lewin’s CELLS, Third Edition includes expanded chapters on Nuclear Structure and Transport, Chromatin and Chromosomes, Apoptosis, Principles of Cell Signaling, The Extracellular Matrix and Cell Adhesion, Plant Cell Biology, and more. All-new design features and a chapter-by-chapter emphasis on key concepts enhance pedagogy and emphasize retention and application of new skills. Thorough, accessible, and essential, Lewin’s CELLS, Third Edition, turns a new and sharper lens on the fundamental units of life.

Eighty years ago, the cellular world opened up. The electron
microscope granted us, for the first time, a detailed
perspective of basic cellular structures, and the ultracentrifuge
allowed us to biochemically isolate and characterize
fractions of cytoplasmic and nuclear material. Geneticists
could investigate the relationship between the ever-�
shifting chromosomal structure and the molecular mechanisms
of genetic inheritance—an effort that culminated
with the triumphant revelation of the structures of DNA
and RNA and a translation of the genetic code.
But we have come a long way from there. We have
perfected our understanding of genes themselves, adjusting
our definition from “determinants of a genetic phenotype,”
to “protein-encoding segments of DNA,” and now,
more precisely, “units of genomic information Â�required for
the transcription of functional messenger RNA or noncoding
RNA.” So far, the complete genomes of over 4,000 organisms
have been published, revealing the sequences
of over 100 million genetic loci. And we are still learning
about the proteins these mRNAs produce. The RSCB
Protein Data Bank (PDB) was established in 1971 as an
international repository for structural data, but it did not
truly begin to grow until the early 1990s. Now, in 2013,
it holds more than 90,000 structures and is expanding
at the rate of about 7,000 structures per year. For now,
X-ray crystallography and nuclear magnetic resonance
are the only techniques available for the determination of
macromolecular structures at high resolution. Important
advances in other methods, however—including visualization
of fluorescently tagged proteins in living cells and
new types of electron microscopy—are describing cellular
structures and processes in ever-increasing detail.
What this all means is that the scope of biological
questions that can be asked has been fundamentally
changed. The new field of structural genomics has enabled
us to relate increased structural resolution to functional
changes, providing powerful insights at deeper levels of
understanding. With our growing ability to process huge
data sets, complete characterizations of cellular structures
such as the nuclear pore complex and the centrosome,
which are constructed from hundreds of proteins, may
soon be attainable.
Perhaps most exciting is the combination of structural
and mechanistic information with developments in genetics,
biochemistry, and physiology—the primary vision of
the emerging field of systems biology. Most cell biologists
today recognize that only a comprehensive approach to
research, from the nuclear pore complex to the extracellular
matrix, will begin to lift the veil from the cellular
processes underlying cystic fibrosis, epilepsy, and cancer.
Any cell biology textbook must provide a current perspective
of the structure, function, and regulation of biological
systems, but in today’s world it is imperative that
we also present the subject in the context of biochemistry
and molecular biology, genomics, histology and pathology,
and physiology. Thoroughly revised and updated, Lewin’s
CELLS, Third Edition turns a new and sharper lens on the
fundamental units of life.
Audience
This third edition, expanded and updated from the second,
is geared for advanced undergraduate and graduate
students taking a first course in cell biology. A key objective
in developing this book was to present the concepts
and mechanisms underlying cell structure and function,
gleaned from decades of research, in a format that provides
students with the information necessary for a solid
foundation in cell biology, without overwhelming them
with too much detail. The major goal of the team of lead
editors and 29 expert authors has been to incorporate the
current research in the field, thoroughly cover each topic,
and provide ample illustrations of cellular processes at the
molecular level—but without being unwieldy.
Design
The design of Lewin’s CELLS, Third Edition is specifically
intended to enhance pedagogy. Chapters are divided into
sections with declarative titles that emphasize the main
points. Each section begins with a set of Key Concepts
that enable readers to grasp the important ideas at the out�-
set. To stimulate students’ interest in future work, chapters
include a section called What’s Next? that Â�describes some
of the interesting questions that researchers are tackling.
Key review articles have been listed for students interested
in the experiments that led to the current understanding
of each topic, and additional references to original
research papers and reviews are available on this book’s
Student Companion Website. Each chapter in Lewin’s
CELLS, Third Edition includes Concept and Reasoning
Checks, allowing students to test their understanding
of the material just presented. Pedagogy has also been
enhanced by adding special feature boxes to highlight
Medical Applications, Historical Perspectives, and
Methods and Techniques used to study cell processes.
The artists, in collaboration with the authors and
editors, have developed the illustrations to be as self-�
explanatory as possible, with such features as label boxes
that lead the reader through a figure. Liberal use of welllabeled
micrographs and molecular structures helps students
to recognize cellular components and understand
relationships between structure and function. Whenever
possible, the schematic figures take into account the relative
sizes of molecules. Colors and molecular shapes, the
latter based on atomic structures where known, are used
in a consistent manner throughout the book.
Supplements to the Text
Jones & Bartlett Learning offers an impressive array of
ancillaries to assist instructors and students in teaching
and mastering the concepts in this text. Additional information
and review copies of any of the following items
are available through your Jones & Bartlett Learning
sales representative or by going to go.jblearning.com
/Cells3e.
For the student
The Navigate Companion Website we have developed
exclusively for the third edition of this text, go.jblearning
.com/Cells3eCW, offers a variety of resources to enhance
understanding of cell biology. Students will find chapter
summaries and study quizzes that help them to review the
key concepts, as well as an interactive glossary, flashcards,
and crosswords to aid with memorization of key terms.
The site also contains a selection of interactive figures,
animations, and videos, visual aids that are �essential to
understanding the dynamic nature of cells. The interactive
figures include diagrams and micrographs with labels that
can be turned on and off as well as short videos with labels
showing the progression of key processes. For those students
who wish to explore topics in cell biology in greater
depth, a list of important research papers and reviews is
also provided for every chapter in the book, along with
links to related sites on the website.
Access to this site is free with every new, printed copy
of the text; it is also available for purchase separately.
Visit go.jblearning.com/Cells3eCW to purchase standalone
�access to the Navigate Companion Website.
For the instructor
Compatible with Windows and Macintosh platforms, the
Instructor’s Media CD provides instructors with the following
traditional ancillaries:
• The PowerPoint Image Bank provides the illustrations,
photographs, and tables (to which
Jones & Bartlett Learning holds the copyright or
has permission to reproduce digitally) inserted into
PowerPoint slides. Instructors can quickly and easily
copy individual images or tables into their existing
lecture slides.
• The PowerPoint Lecture Outline Slides presentation
package provides lecture notes and images
for each chapter of Lewin’s CELLS, Third Edition.
Instructors with the Microsoft PowerPoint software
can customize the outlines, art, and order of
presentation.
• The Instructor’s Media CD also contains more than
350 interactive figures, animations, and videos.
A Test Bank is also available through your Jones & Bartlett
Learning sales representative. The questions are presented
in straight text files that are compatible with most learning
management systems.
George Plopper