A. Mullertz – Analytical Techniques in the Pharmaceutical Sciences (2016)

Автор: A. Mullertz
Название книги: Analytical Techniques in the Pharmaceutical Sciences
Формат: PDF
Жанр: Медицина
Страницы: 832
Качество: Изначально компьютерное, E-book

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood–from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering.

The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.

Topics
Pharmaceutical Sciences / Technology
Biological Techniques
Spectroscopy / Spectrometry
Biomedical Engineering/Biotechnology
Contents
Spectroscopic and Spectrometric Techniques
UV/Vis Spectrophotometry and UV Imaging
Fluorescence Spectroscopy: Basic Foundations and Methods
Mid and Near Infrared Spectroscopy
Raman Spectroscopy
Pharmaceutical Terahertz Spectroscopy and Imaging
Circular Dichroism Spectroscopy for Structural Characterization of Proteins
Applications of Mass Spectrometry in Drug Development Science
Diffractometric Techniques
An Overview of Powder X-ray Diffraction and Its Relevance to Pharmaceutical Crystal Structures
Single-Crystal X-ray Diffraction
Applications of Small Angle X-ray Scattering in Pharmaceutical Science
Thermal Techniques
Thermal Analysis of Pharmaceuticals
Isothermal Microcalorimetry
Separation Techniques
HPLC/UHPLC
Capillary-Based Techniques for Physical-Chemical Characterization of Drug Substances
and Drug Delivery Systems
Asymmetrical Flow Field Flow Fractionation: A Useful Tool for the Separation of Protein Pharmaceuticals and Particulate Systems
Imaging Techniques
Light and Electron Microscopy
Vibrational Spectroscopic Imaging
Magnetic Resonance Imaging and Its Applications to Solid Pharmaceutical Dosage Forms
Mass Spectrometry Imaging of Pharmaceuticals: From Tablets to Tissues
Applications of AFM in Pharmaceutical Sciences
Techniques to Characterize Particles
Particle Size Analysis of Micro and Nanoparticles
Particle Size Measurements in Aerosols
Rheological Techniques
Rheology in Pharmaceutical Sciences
Release and Uptake Testing Techniques
Evaluating Oral Drug Delivery Systems: Dissolution Models
Evaluating Oral Drug Delivery Systems: Digestion Models
Application of Cell Culture and Tissue Models for Assessing Drug Transport