G. Colombo – GABAb Receptor (2016)

Автор: G. Colombo
Название книги: GABAb Receptor
Формат: PDF
Жанр: Медицина
Страницы: 396
Качество: Изначально компьютерное, E-book

An up-to-date comprehensive overview of the GABA B receptor system with a particular focus on the most recent therapeutic applications and potential. This receptor system has recently been implicated in several diseases and disorders including gastroesophageal reflux disease, epilepsy, mood disorders, depression, and alcohol and substance use disorder. The authors, leading researchers in the field, explore a number of approaches, including medicinal chemistry, molecular biology, physiology, and preclinical and clinical pharmacology. This overview provides a translational perspective on the potential of the GABA B receptor pharmacology.

Together with all the authors of the different chapters, I would like to introduce this
book, entirely devoted to the GABAB receptor and part of the prestigious series
named “The Receptors.”
The GABAB receptor is ubiquitously found in the central and peripheral nervous
system, where it contributes to the modulation of neuronal activity. Because of its
broad distribution and considerable involvement in neurotransmission, the GABAB
receptor has been implicated in a range of diseases, and several of its ligands constitute
well-established or promising pharmacotherapies for spasticity, neuropathic
pain, gastroesophageal reflux, epilepsy, autism, anxiety disorder, and substance and
alcohol use disorder.
This volume is intended to provide a series of comprehensive reviews on different
themes related to the GABAB receptor, ranging from the medicinal chemistry of
its ligands (agonists, antagonists, and the more recently synthesized positive allosteric
modulators) (Chaps. 2 and 3) to receptor structure, functioning, distribution, and
mode of action (Chaps. 4–8), and the multiple pharmacological effects produced by
its activation or blockade (Chaps. 9–19). The pharmacology section of this volume
has been organized in such a way that each chapter between 10 and 16 focuses on a
specific disorder or disease that may benefit from therapeutic targeting of the
GABAB receptor; conversely, Chaps. 17–19 focus on specific classes of ligands,
providing a complementary view of the GABAB receptor pharmacology. All chapters
in the pharmacology section have been developed according to a “lab bench to bedside”
translational approach, bridging preclinical animal and clinical data. The book
begins with an historical overview of this research field (Chap. 1), written by Norman
G. Bowery, a “giant” to whom we owe the discovery of the GABAB receptor.
The list of colleagues who have generously accepted to contribute to this volume
includes the most influential scientists in the field, from both academia and
industry. I am indebted to all of them for their enthusiastic and valuable participation
in this book