S. Rosenbaum – Basic Pharmacokinetics and Pharmacodynamics (2017)

Автор: S. Rosenbaum
Название книги: Basic Pharmacokinetics and Pharmacodynamics
Формат: PDF
Жанр: Медицина
Страницы: 588
Качество: Изначально компьютерное, E-book

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action.
Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner
Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules
Features interactive computer simulations, available online through a companion website at: http://www.uri.edu/pharmacy/faculty/rosenbaum/basicmodels.html Adds new chapters on physiologically based pharmacokinetic models, predicting drug–drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications
Reviews of the 1st edition: This is an ideal textbook for those starting out and also for use as a reference book .” (International Society for the Study of Xenobiotics) and I could recommend Rosenbaum s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well–written introduction to PK/PD . (British Toxicology Society Newsletter)
Contents
Introduction to Pharmacokinetics and Pharmacodynamics
Passage of Drugs Through Membranes
Drug Administration and Drug Absorption
Drug Distribution
Drug Elimination and Clearance
Compartmental Models in Pharmacokinetics
Pharmacokinetics of an Intravenous Bolus Injection in a One-Compartment Model
Pharmacokinetics of an Intravenous Bolus Injection in a Two-Compartment Model
Pharmacokinetics of Extravascular Drug Administration
Introduction to Noncompartmental
Pharmacokinetics of Intravenous Infusion in a One-Compartment Model
Multiple Intravenous Bolus Injections in the One-Compartment Model
Multiple Intermittent Infusions
Multiple Oral Doses
Nonlinear Pharmacokinetics
Introduction to Pharmacogenetics
Models Used to Predict Drug–Drug Interactions for Orally Administered Drugs
Introduction to Physiologically Based Pharmacokinetic Modeling
Introduction to Pharmacodynamic Models and Integrated Pharmacokinetic–Pharmacodynamic Models
Semimechanistic Pharmacokinetic–Pharmacodynamic Models
Appendixes
Review of Exponents and Logarithms
Rates of Processes
Creation of Excel Worksheets for Pharmacokinetic Analysis
Derivation of Equations for Multiple Intravenous Bolus Injections
Enzyme Kinetics: Michaelis–Menten Equation and Models for Inhibitors and Inducers of Drug Metabolism
Summary of the Properties of the Fictitious Drugs Used in the Text
Computer Simulation Models