H. Loffler – Atlas of Clinical Hematology (6th edition)

Автор: H. Loffler
Название книги: Atlas of Clinical Hematology (6th edition)
Формат: PDF
Жанр: Клиническая гематология
Страницы: 434
Качество: Изначально компьютерное, E-book

Soon after the 5th edition of this volume appeared, the WHO published details
on the pathology and genetics of the hematopoietic and lymphatic tissues.
Work in progress found in short journal articles had already been integrated
into the last edition. Now it was possible to incorporate the new
proposals for classification and diagnosis and to include figures of new types
of leukemia and lymphoma. These include leukemias of dendritic cells, intravascular
large B-cell lymphoma, the liver-spleen T-cell lymphoma as well
as persistent polyclonal B-cell lymphocytosis, which is placed between benign
and malignant.
The present volume completes and extends the cytogenetic and molecular-
genetic characterization of the different diseases and incorporates new
figures. At this point we would like to thank PD Dr. Claudia Schoch, Munich,
for her valuable help and for graciously providing new zytogenetic and FISH
figures. In addition, several figures and tables were replaced, and a schematic
drawing of the topography of lymphoma infiltration in bone marrow (courtesy
of Prof. Dr. H.E. Schaefer, Freiburg) was added to the lymphoma chapter.
Even in 2004, diagnosis in hematology and lymphomas starts, as a rule,
with the morphological examination of blood, bone marrow or lymphatic
tissues. It can direct the subsequent use of immunophenotyping, cytogenetics
and molecular genetics, in this way demonstrating ways of saving
money and avoiding unnecessary investigations.
Gene expression profiling and, in the future, proteomics still represent
very expensive methods that must find their place in diagnosis and prognostic
evaluation. Gene profiling studies have already confirmed morphological
subtypes in AML, e.g., M3 and M3V, which cannot be distinguished into
strictly separate groups by cytogenetic and molecular-genetic methods.
New therapeutic measures (especially immunotherapy) have brought interesting
progress into the MDS group. For example, the biological entity 5q
minus syndrome, which is well defined by morphology and cytogenetics, responds
very well to treatment with the thalidomide derivative CC 5013. The
fusion gene BCR-ABL, which was originally detected by cytogenesis and is
today routinely detected by FISH or PCR in CML, was the first example of a
specifically tailored molecular therapy in a tumor; certainly other examples
will follow. Cases of ALL involving t(9;22), t(4;11) and t(8;14) have also been
established as separate prognostic groups with special therapeutic problems.
All of these examples demonstrate that a comprehensive arsenal of diagnostic
methods has to be used today for diagnostic and prognostic decisions
and individualized therapeutic planning.
We are again grateful to Prof. Dr. R. Disko of Munich who agreed to revise
and update the chapter on the principal causative agents of tropical diseases.
Finally we wish to thank Mrs. Stephanie Benko and the entire staff of Springer-
Verlag in Heidelberg as well as Ms. Marina Litterer at ProEdit GmbH for
their thoughtful and effective support.