R. Alpern – Seldin and Giebischs the Kidney Physiology and Pathophysiology (5th edition)

Автор: R. Alpern
Название книги: Seldin and Giebischs the Kidney Physiology and Pathophysiology
Формат: PDF
Жанр: Медицина
Год: 2013
Страницы: 3299
Качество: Изначально компьютерное, E-book

A classic nephrology reference for over 25years, Seldin and Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin and Giebisch’s The Kidney is your number one source for information.
Offers the most comprehensive coverage on the market of fluid and electrolyte regulation and dysregulation in 85 completely revised chapters and 10 new chapters
Includes 4sections, 62 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation
Includes foreword by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology and editors of the previous three editions

Preface

As described in its preface, the first edition of The
Kidney: Physiology and Pathophysiology, published in
1985, focused on renal physiology, “conceived broadly
as the study of those processes by which the kidney
maintains the volume and composition of the body in
the face of physiologic demands and pathologic disturbances.”
As noted in the fourth edition, science has
since then become more reductionist, an evolution that
has been reflected in the content of subsequent editions.
Dissection of physiologic phenomena at the level
of organs and cells has been enriched by descriptions
of the roles of individual molecules. While this trend in
science has continued, it has been complemented by a
renewed focus on integrating these molecular functions
to define their roles in cellular and organ physiology,
as well as their role in body homeostasis and disease.
A complete understanding of physiologic and pathophysiologic
processes must include knowledge of
individual molecules, as well as their integration into
homeostatic systems that function to maintain body
composition. A thorough understanding of physiologic
mechanisms endows us with a greater understanding
of pathophysiology and disease. Reciprocally, an
understanding of disease states furnishes us with valuable
information about normal physiology. The present
edition continues to focus on describing the present
state of knowledge of the molecules and the systems
that contribute to normal physiologic function of the
kidney, and the homeostatic mechanisms subserved by
the kidney.
The present edition also concentrates on how these
mechanisms malfunction, resulting in the diseased
state. Again we will address the pathophysiology of
disease states from the molecular to the system level.
One of the appealing features of nephrology is the ability
to utilize our understanding of normal physiology
to elucidate principles of pathophysiology, and secondarily
develop rational approaches to the diagnosis,
treatment, and prevention of disease. Thus, the clinician
addressing a patient with a fluid and electrolyte
disorder need not memorize a list of possible causes or
algorithms, but can logically deduce a solution through
a thorough understanding of kidney function. As science
continues to evolve, our understanding of the
pathophysiologic basis of disease can now be applied to a much broader set of ailments. We continue, therefore,
to broaden the scope of this book so as to place
greater emphasis on mechanisms of disease.
The first section of the textbook begins with general
principles of epithelial and non-epithelial transport
and regulation. This extensive section of the book continues
a tradition established in the first edition, but
extends it to include a more extensive discussion of
transport regulation.
The second section of the book describes the organization
of the kidney with an increased emphasis on the
glomerulus, as this field continues to evolve. There follows
an in-depth review of renal growth and development,
including a discussion of the role of stem cells in
the kidney.
This is then followed by Section Three, describing
mechanisms of fluid and electrolyte regulation and
dysregulation. In no other book can one find this subject
addressed with the depth and thoroughness found
in this textbook. The Fifth Edition includes a more
in-depth discussion of recently described families of
transporters, integrating this information to describe
their role in physiologic and pathophysiologic
processes.
Section Four, the pathophysiology of renal disease,
has been extended as our knowledge of renal dysfunctions
and their contribution to renal ailments has
expanded. Many chapters deal with common everyday
clinical issues, but are presented in the context of
pathophysiologic mechanisms. A series of chapters
focus on mechanisms of progression of renal disease,
as the importance of interrupting or forestalling this
progression has assumed great importance in clinical
nephrology. A thorough understanding of the roles of
glomerular pressure, proteinuria, inflammation, and
oxidants will help researchers and clinicians prevent
renal failure, decreasing the need for dialysis and
transplant.
The evolution of our understanding of kidney function
and dysfunction derives from sequential discoveries
made by a series of investigators, each benefiting
from the accomplishments of their predecessors. The
same can be said for this textbook. Originally conceived
by two of the greatest renal physiologists of the
twentieth century, Donald Seldin and Gerhard Giebisch, it was passed on to Steve Hebert and one of
the present editors. As the present editors, it is our
hope to continue the book’s commitment to science,
and its role in our understanding and practice of
nephrology, and in so doing to honor the previous editors
for all that they have contributed to the book, to
nephrology, to epithelial physiology, and to science in
general