D. Sibley – Handbook of Contemporary Neuropharmacology

Автор: D. Sibley
Название книги: Handbook of Contemporary Neuropharmacology
Формат: PDF
Жанр: Медицина
Страницы: 2579
Качество: Изначально компьютерное, E-book

Written and edited by recognized experts, this comprehensive reference is also available online via Wiley InterScience. Provides a readily accessible reference for students, professionals and libraries alike. Editors are recognized authorities in the neuropharmacology and science field. Comprehensive reference text for active junior and senior neurobiologists. Fills an important niche as a text between research publications and clinical applications.
The “Handbook of Contemporary Neuropharmacology” is an invaluable resource for principal investigators and working scientists in academia, government and industry. This three volume set it also of interest for academic physicians, postdoctoral fellows and residents, and all high-level graduate students.

Neuropharmacology is the study of drugs that affect the nervous system. This
includes not only the identification of neuronal drug targets but also the study of
basic mechanisms of neural function that may be amenable to pharmacological
manipulation. Indeed, neuropharmacological drugs are commonly used as valuable
tools to discover how nerve cells function and communicate in addition to
therapeutic agents for the treatment of a wide variety of neuropsychiatric disorders.
In fact, drugs that are used to treat disorders of the brain and nervous system
represent one of the largest groups of approved therapeutic agents. Clearly the
demand for drugs to treat disorders of the nervous system will only grow in the face
of an aging population. Not surprisingly, almost all major pharmaceutical corporations
and many biotechnology companies have extensive drug discovery programs in
neuroscience and neuropharmacology. The recent pace of research and discovery in
neuropharmacology and associated therapeutics has been quite rapid, as is true for
most areas of biomedical research. Given this as well as the extremely broad nature
of the field, we felt that it would be timely and important to develop a comprehensive
handbook of neuropharmacology that would include state-of-art reviews covering
both basic principles and novel approaches for clinical therapeutics.
Our approach for the organization of this handbook was primarily translational
(bench to bedside) in nature. The three book volumes consist of 10 clinical sections,
each consisting of 4–7 chapters devoted to various neuropsychiatic disorders,
including mood, anxiety, and stress disorders, psychosis, pain, neurodegeneration,
and many others. In most cases, these sections have introductory chapters providing
background information and/or basic principles prior to presenting chapters covering
state-of-the-art therapeutics. Volume I also contains a large introductory section
consisting of 17 chapters on basic neuropharmacological subjects and principles.
These include chapters on the history of neuropharmacology as well as intercellular
and intracellular signaling followed by chapters covering all of the major neurotransmitter
systems and other important signaling molecules, such as ion channels
and transporters. Our objective for this project was to create a high-level reference
work that will be useful to all practitioners of neuropharmacology ranging from
graduate students, academicians, and clinicians to industrial scientists working in
drug discovery. These volumes will be part of the John Wiley & Sons major reference
work program and will be published online as well as in print. The online version of
this handbook is expected to undergo frequent updates and additions in order to
maintain its cutting-edge status.
The editors would like to thank all of the chapter contributors for their hard work
and commitment to this project. We would also like to thank our managing editor,
Jonathan Rose, at John Wiley & Sons for all of the valuable assistance that he has
provided.
David R. Sibley