P. Peterson – Neuroinflammation and Neurodegeneration

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Автор: P. Peterson
Название книги: Neuroinflammation and Neurodegeneration
Формат: PDF
Жанр: Нейрофизиология человека
Страницы: 606
Качество: Изначально компьютерное, E-book

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Описание

The BloodBrain Barrier
Immune Cell Trafficking in the Central Nervous System
General Physiology and Pathophysiology of Microglia
Inflammation and the Pathophysiology of Astrocytes in Neurodegenerative Diseases
Oxidative Stress, Neuroinflammation, and Neurodegeneration
Peripheral Neuroimmune Interactions and Neuropathic Pain
Innate and Adaptive ImmuneMediated Neuroinflammation and Neurodegeneration in Parkinson’s Disease
Multiple Sclerosis: Impact on Functioning of the Blood–Brain Barrier
Neuroinflammation in Alzheimer’s Disease
Neuroinflammation in Huntington’s Disease
Neuroinflammation and Immune Regulation in Ischemic Stroke: Identification of New Pharmacological Targets
Front Matter
HIV/NeuroAIDS
Herpes Simplex Virus Infections of the Central Nervous System
Congenital Cytomegalovirus Disease
Japanese Encephalitis: A Tale of Inflammation and Degeneration in the Central Nervous System
The Biology and Clinical Consequence of Infection with the Human Polyomavirus JCV
Role of RetrovirusInduced Transactivator Proteins in Neuroinflammatory Disease
Immunopathogenesis of Bacterial Meningitis
Cerebral Malaria
HIV and Cocaine Interplay in HIVAssociated Neurocognitive Disorders
Front Matter
Methamphetamine Neurotoxicity and Neuroinflammatory Processes
Drugs of Abuse and NeuroAIDS: Opiates
Cannabinoids
Alcohol and Neurodegeneration
CellBased Drug Delivery for Improving Antiretroviral Therapeutic Outcomes
Immunomodulatory Therapeutics
Therapeutic Potential of Cannabinoids

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