S. Dumitriu – Polymeric Biomaterials (2nd edition)

Автор: S. Dumitriu
Название книги: Polymeric Biomaterials
Формат: PDF
Жанр: Биологические науки
Страницы: 1183
Качество: Изначально компьютерное, E-book

The need for spare parts for the human body has never been greater than at present. More people than ever are living longer, but the human body, shaped by millions of years of evolution, isn’t keeping up. Spare parts must be available to replace organs and tissues that are worn out from operating beyond their expiration dates, as well as those damaged by injury, disease, or developmental mishaps. The biomaterials field has come a long way from its empirical beginnings, with researchers taking whatever materials were available and attempting to integrate them into the human body, sometimes with disastrous results. Now, the body’s response to foreign materials is better understood than ever before. Furthermore, the past 15 years have seen great strides in tissue engineering. Spare parts consisting of living tissues are poised for significant clinical application. Tissue engineering, especially of tissues derived from the patient’s own cells, offers total acceptance by and integration with the patient’s body, unlike nonliving materials or living tissues from other humans or species.
Contents
Preface
Contributors
Polymers as Biomaterials
Polysaccharides as Biomaterials
Biomimetics
Silicones for Pharmaceutical and Biomedical Applications
Biodegradable Polymers as Drug Carrier Systems
Biodegradable Biomaterials Having Nitric Oxide Biological Activity
Hydrogels for Biomedical and Pharmaceutical Applications
Mucoadhesive Polymers
Polymers for Tissue Engineering Scaffolds
Chitosan: Structure-Properties Relationship and Biomedical Applications
Chitosan-Based Delivery Systems: Physicochemical Properties and Pharmaceutical Applications
Immobilization of Active Biopolymers from Cold Plasma-Functionalized Surfaces for the Creation of Molecular Recognition and Molecular Manufacturing Systems
Advances in Designed Multivalent Bioconjugates with Dendritic Structure
Biocompatibility of Elastomers
Control of Cell-Biomaterial Interactions
Medical and Pharmaceutical Applications of Polymers
Polymeric Systems for Ophthalmic Drug Delivery
Dental and Maxillofacial Surgery Applications of Polymers
Biomaterials in Burn and Wound Dressings
Dermocosmetic Applications of Polymeric Biomaterials
Textile-Based Biomaterials for Surgical Applications
Bioabsorbable Polymers for Medical Applications with an Emphasis on Orthopedic Surgery
Polymers for Artificial Joints
Polymeric Occluders in Tilting Disc Heart Valve Prostheses
Blood-Contacting Polymers
Surface Modification of Dacron Vascular Grafts: Incorporation of Antithrombin and Mitogenic Properties
Antithrombin-Heparin Complexes
Adhesives for Medical Applications
Glucose-Sensitive Hydrogel Membranes
Polymeric Micro- and Nanoparticles as Drug Carriers
Liposomes in Drug Delivery
Liposomes for Cancer Therapy Applications
Systemic Cancer Therapy Using Polymer-Based Prodrugs and Progenes
Anticancer Drug Conjugates with Macromolecular Carriers
Enzyme-Prodrug Therapies of Cancer
New Lipid/DNA Complexes for Gene Delivery
Gene Delivery by Cationic Liposome-DNA Complexes
Biological Stimulus-Responsive Hydrogels
Biocompatible Polymers in Liver-Targeted Gene Delivery Systems
Bioartificial Pancreas
Transdermal Delivery of Drugs
Drug Delivery via Mucosal Routes
Bioadhesive Drug Delivery Systems
Recent Developments in Drug Delivery to the Nervous System
Glucose-Mediated Insulin Delivery from Implantable Polymers
Drug Targeting to the Kidney: The Low-Molecular-Weight Protein Approach