G. Steinhoff – Regenerative Medicine. From Protocol to Patient (3rd edition, 5 Volume set, 2016)

Автор: G. Steinhoff
Название книги: Regenerative Medicine. From Protocol to Patient (3rd edition, 5 Volume set, 2016)
Формат: PDF
Жанр: Медицина
Страницы: 378+458+257+374+404
Качество: Изначально компьютерное, E-book

Volume 1: Biology of Tissue Regeneration

Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology, as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine.
Volume 1 contains eleven chapters addressing the latest basic science knowledge on the “Biology of Tissue Regeneration”. The principles of cell regeneration control by extracellular matrix and the biology of stem cell niches are explained. Depicted are the principles of molecular mechanisms controlling asymmetric cell division, stem cell differentiation, developmental and regenerative biology, epigenetic and genetic control as well as mathematical modelling for cell fate prediction. Regenerative biology of stem cells in the central nervous and cardiovascular systems leading to complex tissue regeneration in the model species axolotl and zebrafish, as well as the impact of immune signalling on nuclear reprogramming are outlined. These up to date accounts gives the readers advanced insights into the biological principles of the regenerative processes in stem cells, tissues and organisms.
Extracellular Matrix and Tissue Regeneration
Stem Cell Niche
Stem Cells and Asymmetric Cell Division
Stem Cells in the Developing and Adult Nervous System
Epigenetic Mechanisms Regulating the Transition from Embryonic Stem Cells Towards a Differentiated Neural Progeny
Mathematical Models in Stem Cell Differentiation and Fate Predictability
Organ and Appendage Regeneration in the Axolotl
Development and Regeneration of the Vertebrate Brain
Role of Innate Immune Signaling in Nuclear Reprogramming
Cardiac Regeneration in Zebrafish
Genetics and Regeneration in Vertebrates

Volume 2: Stem Cell Science and Technology
Volume 2 contains sixteen chapters addressing advanced knowledge on “Stem Cell Science and Technology” addressing basic classification technology, cell biology of stemness state and regulatory molecular pathways. Mechanisms and technology of cell programming are explained, as well as the pathology of cancer cells and dedifferentiation signalling. Pluripotent, multipotent germline and tissue specific human stem cells are classified and qualified according to their respective biological function or tissue regeneration. Leading stem cell scientists from all over the world explain advanced technology, latest knowledge, and clinical implications of human stem cell science in a unique, comprehensive and detailed outline
Characterization and Classification of Stem Cells
Human Embryonic Stem Cells
Induced Pluripotent Stem Cells in Regenerative Medicine
Spermatogonial Stem Cells
Hematopoietic Stem Cells
Stem Cells for Cardiovascular Regeneration
Neural Stem Cells
Liver Stem Cells
Intestinal Stem Cells in Homeostasis and Cancer
Cancer Stem Cells: Perspectives Beyond Immunophenotypes and Markers
Mesenchymal Stromal Cells (MSC)
Musculoskeletal Stem Cells
Pancreas-Derived Multipotent Progenitors
Adipose-Derived Stem/Stromal Cells
Cell Programming for Future Regenerative Medicine
Parthenogenesis

Volume 3: Tissue Engineering, Biomaterials and Nanotechnology
Contents
Novel Concepts in Design and Fabrication of ‘Living’ Bioprosthetic Heart Valves: From Cell Mechanosensing to Advanced Tissue Engineering Applications
Recent Progress in Strategies for Adenovirus Mediated Therapeutic Cell Targeting
Regenerative Chimerism Bioengineered Through Stem Cell Reprogramming
Biodegradable Polymeric Materials
Biomaterials-Enabled Regenerative Medicine in Corneal Applications
Functionalized Nanomaterials
Biointerface Technology
Controlled Release Technologies for RNAi Strategies in Regenerative Medicine
Imaging Technology

Volume 4: Regenerative Therapies I
Topics.
Molecular Medicine.
Stem Cells.
Biomaterials.
Contents.
History of Regenerative Medicine.
Regulatory Framework for Cell and Tissue Based Therapies in Europe.
Ethics and Law in Regenerative Medicine.
Guidelines for Preclinical Development.
Regenerative Medicine in the Central Nervous System: Stem Cell-Based Cell- and Gene-Therapy.
Regenerative Therapy for Central Nervous System Trauma.
Peripheral Nervous System: Regenerative Therapies.
Regenerative Therapies for the Ocular Surface.
Regenerative Therapies for Retinopathy.
Lacrimal Gland Regeneration: Progress and Promise.
The Development of a Stem Cell Therapy for Deafness.
Oral and Maxillo-Facial.
Regenerative Therapies – Trachea.
Stem Cell Therapy for Neonatal Lung Diseases.

Volume 5: Regenerative Therapies II
Volume 5 contains clinical science and translation surveys on the circulatory system, visceral, musculoskeletal and skin. The state-of-the-art descriptions involve concepts for clinical diagnosis, stem cell and gene therapy, biomaterials for tissue replacement and pharmacological/biomolecule treatment strategies.
Biology of Tissue Regeneration (Volume 1) focuses on regenerative biology with chapters on extracellular matrix, asymmetric stem cell division, stem cell niche regulation, (epi)genetics, immune signalling, and regenerative biology in organ systems and model species as axolotl or zebrafi sh.
Stem Cell Science and Technology (Volume 2) provides an overview as classifi cation of stem cells and describes techniques for their derivation, programming and culture. Basic properties of differentiation states as well as function in human organism are illustrated, and areas of stem cell pathologies in cancer and therapeutic applications for these cells are discussed with emphasis on their possible use in Regenerative Medicine.
Tissue Engineering, Biomaterials and Nanotechnology (Volume 3) focuses the development of technologies, which enable an effi cient transfer of therapeutic genes and drugs exclusively to target cells and potential bioactive materials for clinical use. Principles of tissue engineering, vector technology, multifunctionalized nanoparticles and nanostructured biomaterials are described with regard to the technological development of new clinical cell technology. Imaging and targeting technologies as well as biological aspects of tissue and organ engineering are depicted.
Regenerative Therapies I (Volume 4) gives a survey on history of Regenerative Medicine and clinical translation including regulation, ethics, and preclinical development. Clinical state-of-the art, disease-specifi c approaches of new therapies, application technology, clinical achievements, and limitations are described for the central nervous system, head and respiratory system. Regenerative Therapies II (Volume 5) contains state-of-the-art knowledge and clinical translation of Regenerative Medicine in the cardiovascular, visceral and musculoskeletal systems.
Blood
Vascular Regeneration Therapy: Endothelial Progenitor Cells for Ischemic Diseases
Heart
Myocardial Pharmacoregeneration
Liver
Gastrointestinal Tract and Endocrine System
Kidney
Urogenital Tract
Bone
Articular Cartilage Regeneration
Muscle, Ligament and Tendon Regeneration
Regenerative Therapies