G. Wondrak – Stress Response Pathways in Cancer (2015)

Name: G. Wondrak - Stress Response Pathways in Cancer (2015)
SKU: 29685
Price: 2275 RUB
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Автор: G. Wondrak
Название книги: Stress Response Pathways in Cancer
Формат: PDF
Жанр: Медицина
Страницы: 450
Качество: Изначально компьютерное, E-book

It is now established that dysregulated cell stress response pathways play a critical role in tumorigenesis, and a refined mechanistic understanding of this phenomenon at the molecular level promises to open new avenues for targeted therapeutic strategies that may benefit cancer patients in the near future. Coauthored by recognized leaders in cancer research from five continents, this novel book provides a comprehensive perspective on cell stress response pathways and therapeutic opportunities. Focusing on the role of genotoxic, proteotoxic, oxidative, metabolic, and inflammatory stress in tumorigenesis, the book is essential reading for students, basic researchers, and biomedical health care professionals interested in cancer and therapeutic development.
Introduction to Cell Stress Responses in Cancer: The Big Picture
DNA Repair Dysregulation in Cancer: From Molecular Mechanisms to Synthetic Lethal Opportunities
Cell Cycle Checkpoint and DNA Damage Response Defects as Anticancer Targets: From Molecular Mechanisms to Therapeutic Opportunities
p53 at the Crossroads Between Stress Response Signaling and Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
Sirtuins as a Double-Edged Sword in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
MicroRNA Regulated Stress Responses in Cancer
Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities
Pro-senescence Therapy for Cancer: Time for the Clinic
Integrating Proteotoxic Stress Response Pathways for Induction of Cell Death in Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities
The Hsp70 Family of Heat Shock Proteins in Tumorigenesis: From Molecular Mechanisms to Therapeutic Opportunities
The Ubiquitin-Proteasome System (UPS) as a Cancer Drug Target: Emerging Mechanisms and Therapeutics
Endoplasmic Reticulum Stress in Multiple Myeloma: From Molecular Mechanisms to Therapeutic Opportunities
Melanomagenic Gene Alterations Viewed from a Redox Perspective: Molecular Mechanisms and Therapeutic Opportunities
Targeting Hypoxic Adaptations of Cancer Cells: Molecular Mechanisms and Therapeutic Opportunities
Targeting Glycolytic Adaptations of Cancer Cells: From Molecular Mechanisms to Therapeutic Opportunities
At the Crossroads Between Mitochondrial Metabolite Transport and Apoptosis: VDAC1 as an Emerging Cancer Drug Target
Inflammatory Dysregulation and Cancer: From Molecular Mechanisms to Therapeutic Opportunities
Cell-Nonautonomous ER Stress-Mediated Dysregulation of Immunity by Cancer Cells

Категории: Биологические науки, Медицина, Онкология, Электронные книги Метки: Stress Response Pathways in Cancer, Wondrak

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G. Wondrak – Stress Response Pathways in Cancer (2015) — научное издание, которое подробно разбирает молекулярные механизмы, с помощью которых раковые клетки используют и модифицируют сигнальные пути ответа на стресс для своего выживания, роста и устойчивости к терапии.

Книга рассматривает ключевые стрессовые сигнатуры — окислительный, генотоксический, метаболический и протеотоксический стресс, а также роль Nrf2, HSF1, UPR и других регуляторных белков в онкогенезе. Особое внимание уделяется тому, как эти пути можно терапевтически «перепрограммировать» для повышения эффективности противоопухолевых препаратов.

онкологам и исследователям, изучающим молекулярные основы рака
специалистам в области фармакологии и разработки новых противоопухолевых агентов
студентам и аспирантам биологических и медицинских специальностей, интересующимся сигнальными путями
биологам, работающим в области клеточного стресса и протеостаза