P. Gopalakrishnakone – Snake Venoms (2017)

Автор: P. Gopalakrishnakone
Название книги: Snake Venoms
Формат: PDF
Жанр: Яды змей
Страницы: 511
Качество: Изначально компьютерное, E-book

Initially, because of the inadequate sensitivity of devices and other limitations, only major venom components of the dominant species were studied. However, in last two decades, increased sensitivity of devices and the development of new techniques, such as transcriptomics and proteomics techniques, have permitted us to analyze the structures and functions of rare species and to identify novel minor components.
As a result, the number of venom components identified is increasing dramatically and the physiological functions of each component is more deeply understood. The scope of this book provides the readers an updated and comprehensive presentation on snake venoms. The subjects are divided into six sections, starting with the overview of snake venom compositions in Malaysian species, followed by description of enzymes and enzyme inhibitors contained in snake venoms. Also discussed are the effects of snake venom on cellular receptors, ion channels, blood, and lymph, as well as cytotoxic and antimicrobial molecules present in snake venoms. The last section covers the clinical consequences of envenomation and the management of snakebites using antivenins.
Contents
Composition of Snake Venoms
Toxinology of Snake Venoms: The Malaysian Context
Snake Venom Enzymes and Enzyme Inhibitors
Cellular Mechanisms of Action of Snake Phospholipase A2 Toxins
Secreted Phospholipases A2 with β-Neurotoxic Activity
Anticoagulant and Membrane Damaging Properties of Snake Venom Phospholipase A2 Enzymes
Phospholipase A2 Inhibitors from Snake Blood (sbPLIs)
A Brief Appraisal on Russell’s Viper Venom (Daboia russelii russelii) Proteinases
Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom
Snake Venom Protease Inhibitors: Enhanced Identification, Expanding Biological Function, and Promising Future
Snake Venom Effects on Receptor and Ion Channel
Snake Venom Toxins Targeted at the Nervous System
Snake α-Neurotoxins and the Nicotinic Acetylcholine Receptor
Structural and Functional Diversity of Snake Sarafotoxins
Crotamine: Function Diversity and Potential Applications
Cytotoxic Effects
Vipericidins, Snake Venom Cathelicidin-Related Peptides, in the Milieu of Reptilian Antimicrobial Polypeptides
Cytotoxic Effects of Snake Venoms
Snake Venom Effects on Blood and Lymph
Cobra Venom Factor: The Unique Component of Cobra Venom That Activates the Complement System
Non-Cobra Venom Factor Venom Components Acting on Complement Proteins
Snake Venom Components Affecting the Coagulation System
Snake Venom Disintegrins
Snake Envenomation and Snakebite Management
Role of Lymphatic System on Snake Venom Absorption
Antivenom Safety and Tolerance for the Strategy of Snake Envenomation Management