Ralph A. DeFronzo – International Textbook of Diabetes Mellitus (4th edition, 2015)

Автор: Ralph A. DeFronzo
Название книги: International Textbook of Diabetes Mellitus (4th edition)
Формат: PDF
Жанр: Сахарный диабет
Страницы: 1130
Качество: Изначально компьютерное, E-book

The “International Textbook of Diabetes Mellitus” has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, “ITDM's” primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease.

Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes.

This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available.

As the epidemic of diabetes continues to expand in parallel
with the rapid spread of obesity, healthcare providers strive
to find interventions to reduce the morbidity, mortality, and
rising costs associated with this devastating disease, which
ravages both the micro- and the macrovasculature. Although
the increase in incidence of type 2 diabetes may be attributed
to the expanding girth of the population coupled with a lack of
physical activity, the marked increase in the incidence of type 1
diabetes remains unexplained. Our knowledge of the cellular,
biochemical, and molecular etiology of impaired insulin action
and beta-cell failure has expanded enormously, but the genetic
basis of both type 1 and type 2 diabetes and their associated
complications is still by and large undefined. Despite the introduction
of multiple new classes of antidiabetic agents for the
treatment of type 2 diabetes, and newer insulin preparations,
insulin delivery systems, and glucose-sensing devices for the
management of type 1 diabetes, glycemic control is suboptimal
in approximately half of all diabetic patients and the excess
risk for macrovascular complications is largely unexplained.
In many parts of the world, these treatment advances are not
available and instituting behavioral modification programs at
the societal and individual level is proving to be inadequate
in curbing the growing epidemic of obesity. Whether the
introduction of novel weight loss medications will stem the tide
of obesity remains to be determined.
The fourth edition of the International Textbook of Diabetes
Mellitus will continue to be themost widely referenced textbook
of diabetes worldwide and draws upon the expertise of leading
basic scientists, clinicians, educators, and healthcare professionals
globally to provide the most updated information on
advances in diabetes research and clinical care. This information
will be an invaluable resource and provide the practicing
physician, as well as the basic scientist and clinical investigator,
with the requisite resources to advance them to the frontiers of
biomedical research in the fields of diabetes, metabolism, and
obesity and to provide them with state-of-the-art knowledge to
optimize clinical care for their diabetic patients.