C. Vauthier – Polymer Nanoparticles for Nanomedicines (2016)

Автор: C. Vauthier
Название книги: Polymer Nanoparticles for Nanomedicines
Формат: PDF
Жанр: Нанотехнологии
Страницы: 649
Качество: Изначально компьютерное, E-book

Polymers are macromolecules composed of many repeated subunits of different nature, leading to a broad range of compositions and properties. Both synthetic and natural polymers play a major role in the life sciences. Whereas natural polymers (nucleic acids, proteins, peptides) are the building blocks of biological structures and functions and are the support of genetic and epigenetic events, the polymerization of monomers through various modern synthetic routes (e.g., controlled anionic or radical polymerization, ring-opening polymerization, etc.) enables the design of synthetic polymers with unique physicochemical properties, including robustness, viscoelasticity, and a tendency to form glasses and semicrystalline structures rather than crystals. They may be combined to form tailor-made supramolecular architectures. The versatility of these polymer structures and the resulting properties offer many applications in the medical and pharmaceutical fields. «Smart» polymers, designed to undergo reversible physical or chemical changes in response to environmental stimuli (such as temperature, light, magnetic or electric field, pH, ionic strength or enzymes) also hold great promise as drug delivery systems, tissue engineering scaffolds, cell culture supports, bioseparation devices, sensors, and even actuators systems. Because of their extraordinary versatility, there is an increased interest to use polymers, either natural or synthetic, as transporter material for the design of nanomedicines.
Contents
Methods for the Manufacturing of Nanoparticles: Principles
Polymer Nanoparticles for In Vivo Applications: Progress on Preparation Methods and Future Challenges
Nanoprecipitation Process: From Particle Preparation to In Vivo Applications
Targeted Theragnostic Nanoparticles Via Flash Nanoprecipitation: Principles of Material Selection
Preparation of Polymer Nanoparticles by the Emulsification-Solvent Evaporation Method: From Vanderhoff’s Pioneer Approach to Recent Adaptations
Methods for the Preparation of Nanoparticles by Polymerization
Shape-Controlled Nanoparticles for Drug Delivery and Targeting Applications
Characterization of Polymer Nanoparticles Designed as Nanomedicines
Physicochemical Characterization of Polymer Nanoparticles: Challenges and Present Limitations
Imaging Polymer Nanoparticles by Means of Transmission and Scanning Electron Microscopy Techniques
Evaluating the Interactions Between Proteins and Components of the Immune System with Polymer Nanoparticles
Investigating Interactions Between Nanoparticles and Cells: Internalization and Intracellular Trafficking
Turning Polymer Nanoparticle Technologies into Nanomedicines
Designing Polymer Nanoparticle Nanomedicines: Potential Applications and Challenges
Selecting and Designing Polymers Suitable for Nanoparticle Manufacturing
Associating Drugs with Polymer Nanoparticles: A Challenge
Drug Delivery by Polymer Nanoparticles: The Challenge of Controlled Release and Evaluation
Interaction Between Nanoparticles and Plasma Proteins: Effects on Nanoparticle Biodistribution and Toxicity
Toxicological Aspects of Polymer Nanoparticles
Theranostics: In Vivo
From Lab to Prescription Desk
Nanomedicines—A Scientific Toy or an Emerging Market?
Regulatory Perspective on the Development of Polymer Nanomaterials