E. Buxbaum – Fundamentals of Protein Structure and Function (2015)
3.440 ₽
Автор: E. Buxbaum
Название книги: Fundamentals of Protein Structure and Function (2015)
Формат: PDF
Жанр: Биологические науки
Страницы: 521
Качество: Изначально компьютерное, E-book
This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance.
This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses.
About the author:
Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.
Описание
E. Buxbaum — Fundamentals of Protein Structure and Function (2015) — это современное учебное пособие, которое объясняет принципы строения и работы белков с точки зрения биохимии и биофизики. Автор подробно рассматривает, как аминокислотная последовательность определяет пространственную структуру и функциональные свойства белковых молекул.
Книга охватывает ключевые темы: уровни организации белка, методы определения структуры (рентгеноструктурный анализ, ЯМР, крио-ЭМ), ферментативный катализ, регуляцию активности, транспортные и моторные белки, а также принципы взаимодействия белков с лигандами. Особое внимание уделено связи структуры с функцией и примерам заболеваний, связанных с нарушением фолдинга.
- Студентам биологических, медицинских и химических специальностей
- Начинающим исследователям в области молекулярной биологии и биохимии
- Специалистам в диетологии и нутрициологии, интересующимся белковым обменом
- Всем, кто хочет глубоко понять, как устроены белки и почему это важно для здоровья
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