Johannis P. Kamerling – Comprehensive Glycoscience from Chemistry to Systems Biology

Автор: Johannis P. Kamerling
Название книги: Comprehensive Glycoscience
Формат: PDF
Жанр: Химия
Страницы: 3294
Качество: Изначально компьютерное, E-book

Carbohydrates are an important part of life and are present in bacteria, fungi, viruses, yeast, plants, animals and humans.
The rapid expansion of chemistry and glycobiology over the last few years has provided many new, imaginative and efficient techniques which provide further insight into the structures and biological interactions of carbohydrates and glycostructures.
This work has a very broad scope and will appeal to a wide audience as it explores the interactions between biology, chemistry and molecular biology towards understanding, synthesising and developing glycoproteins, glycolipids, proteoglyans and polysaccharides, which are important molecules in nature for controlling health and disease and food and feed.

Glycocompounds reviewed include: oligosaccharides, polysaccharides, glycoproteins, glycolipids, glycoconjugates, lectins, cellulose, pectins and starch.

Topics covered include: spectroscopy, nomenclature, structures, synthesis, biosynthesis, molecular interactions, degradation, biochemistry, glycobiology, glycotherapeutics and diseases.

· Combines multiple aspects of glycoscience in one comprehensive work
· Documents the new and rapid expansion of carbohydrate chemistry and glycobiology over the last few years
· Highlights the many new, imaginative and efficient techniques for providing insights into carbohydrates and glycostructures

In terms of sub-topics, the world of carbohydrates is an extremely heterogeneous world. Quite often,
only the word ‘carbohydrate’ forms a connection between the different continents. Although (poly)
saccharides have already been in use for decades in various industrial applications, and polysaccharidebased
vaccines are on the market, new developments make them challenging for deep investigations
and novel (biomolecular) applications. But nowadays carbohydrate biochemistry and molecular biology
focused on glycoconjugates may also rejoice in a high level of interest from the biomedical and
pharmaceutical side. Carbohydrate-mediated communication between biomolecules on the molecular
level, glycoprotein engineering, and oligo- and polysaccharide immunology are all aspects of this fast
growing area. Structural analysis including conformational analysis and organic/enzymatic synthesis of
carbohydrates are cornerstones of nearly all of the developments mentioned. It is evident that carbohydrate
research/glycoscience on a high level can only be successful in a multidisciplinary approach.
After genomics and proteomics, glycomics is also ready for a key position in life sciences.
Comprehensive Glycoscience brings together glycochemistry, glycoanalysis, glycobiology, glycomedicine,
glyco(bio)technology, food and industrial glycoscience, and glycobioinformatics – glycoproteins,
glycolipids, proteoglycans, glycosylphosphatidylinositol anchors, and polysaccharides – the microbial,
animal, plant, and human world – health and disease. In a collection of 118 chapters in four volumes,
and in the electronic version via Science Direct, highly-recognized glycoscientists (academic and
industrial scientists, polysaccharide experts and glycoconjugate experts, chemists of all disciplines,
biochemists, biologists, and medical doctors) give insight into their glycoworld. Volume 1 contains
23 chapters that give an Introduction to Glycoscience and then focuses on the Organic and Enzymatic
Synthesis of Carbohydrates. Volume 2, also of 23 chapters, deals with Analysis and Structural Aspects
of Glycans as well as with Polysaccharide Functional Properties. Then, in Volume 3, with 36 chapters,
attention is paid to the Biochemistry of Glycoconjugate Glycans and to Carbohydrate-mediated Interactions.
Finally, in Volume 4, also of 36 chapters, Cell Glycobiology and Development as well asHealth and
Disease in Glycomedicine are the topics of interest.
The glycoknowledge is discussed by the authors on a basic (tutorial) level as well as on a more
advanced level, depending on the topic. Referring to older reviews and key papers discloses the
glycoliterature broadly. This makes Comprehensive Glycoscience a real encyclopedia for master
students, Ph.D. students, professors, and industrial scientists, interested in the state of the glyco-art.
Johannis P. Kamerling