Rexford S. Ahima – Metabolic Basis of Obesity

Автор: Rexford S. Ahima
Название книги: Metabolic Basis of Obesity
Формат: PDF
Тема: Эндокринология, Ожирение
Страницы: 406
Качество: Изначально компьютерное, E-book

The obesity epidemic has generated immense interest in recent years due to the wide-ranging and significant adverse health and economic consequences that surround the problem. Much attention has been focused on behaviors that lead to obesity, in particular to over consumption of energy-dense food and to sedentary lifestyle. However, obesity is an extremely complex condition with poorly defined pathogenesis. Thanks to greatly enhanced research in the area, the discovery of pathways in the brain and peripheral organs that mediate energy homeostasis has provided a framework for understanding the biological basis of obesity. Metabolic Basis of Obesity adds an important new dimension to the growing literature on obesity by offering a comprehensive review of specifically how metabolic imbalance culminates in obesity. Developed by a team of expert authors, this important title discusses the principles of energy balance, genetics of body weight regulation, hormones and adipokines, and metabolic pathways in the brain, liver, muscle and fat, to name just several of the areas covered. The book also examines the connection between obesity and diabetes, cardiovascular disease and other complications. Current and future diagnostic and treatment strategies are also reviewed. Comprehensive and timely, Metabolic Basis of Obesity is an essential reference for understanding the burgeoning problem of obesity.
Contents:
Principles of Human Energy Metabolism
Intermediary Metabolism of Carbohydrate, Protein, and Fat.
Adipose Tissue Development, Structure and Function
Adipokines in Health and Disease
Neural Control of Feeding and Energy Homeostasis
Gastrointestinal Hormones and Obesity
Genes and Human Obesity
Classical Hormones Linked to Obesity
Inflammation and Adipose Dysfunction
Insulin Resistance in the Metabolic Syndrome
Pancreatic Islet b-Cell Failure in Obesity
Non-Alcoholic Fatty Liver Disease and the Metabolic Syndrome
Sleep, Circadian Rhythms and Metabolism
Obesity and Cardiac Dysfunction
Atherogenic Lipid Metabolism in Obesity
Gut Microbes, Immunity, and Metabolism
Impact of Obesity on Female Reproductive Health
Lessons from HIV Lipodystrophy and Drug-Induced Metabolic Dysfunction
Principles of Obesity Therapy